191
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer’s Disease Mouse Model: Role of Microglial and Neuroinflammation

, , , , ORCID Icon, , , , , , , & show all
Pages 69-79 | Received 21 Jul 2023, Accepted 05 Oct 2023, Published online: 25 Oct 2023

Figures & data

Figure 1 Influence of leptin on the levels of Aβ1-40 (Left) and Aβ1-42 (Right) in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 1 Influence of leptin on the levels of Aβ1-40 (Left) and Aβ1-42 (Right) in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 2 Western blotting analysis of synaptophysin expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 2 Western blotting analysis of synaptophysin expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 3 Semi-quantitative analysis of synaptophysin expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 3 Semi-quantitative analysis of synaptophysin expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 4 Leptin increased microglial cell number in the hippocampus of adult mice, but not aged mice. (AD) Representative images of Iba-1+ cells, in the hippocampus sections of the mice. (EG) Quantitative analysis of Iba-1+ stained cells.

Figure 4 Leptin increased microglial cell number in the hippocampus of adult mice, but not aged mice. (A–D) Representative images of Iba-1+ cells, in the hippocampus sections of the mice. (E–G) Quantitative analysis of Iba-1+ stained cells.

Figure 5 Influence of leptin on the levels of IL-1β (Left), IL-6 (Right) in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 5 Influence of leptin on the levels of IL-1β (Left), IL-6 (Right) in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 6 Western blotting analysis of leptin receptor expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 6 Western blotting analysis of leptin receptor expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 7 Semi-quantitative analysis of leptin receptor expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.

Figure 7 Semi-quantitative analysis of leptin receptor expression in the adult + leptin group, adult + saline group, aged + leptin group and aged + saline group.