Figures & data
Figure 1 Vasculogenesis in the newborn dog.
Abbreviation: ADPase, adenosine diphosphatase.
![Figure 1 Vasculogenesis in the newborn dog.](/cms/asset/e3284532-a603-4ad3-9f97-9e450e6aeb26/deyb_a_94443_f0001_c.jpg)
Figure 2 Vaso-obliteration in the dog model of OIR.
Abbreviations: OIR, oxygen-induced retinopathy; ADPase, adenosine diphosphatase.
![Figure 2 Vaso-obliteration in the dog model of OIR.](/cms/asset/2c7314eb-4545-4588-b4a3-e622704b88fb/deyb_a_94443_f0002_b.jpg)
Figure 3 Hyperoxia affects all regions uniformly in the dog OIR model.
Abbreviation: OIR, oxygen-induced retinopathy.
![Figure 3 Hyperoxia affects all regions uniformly in the dog OIR model.](/cms/asset/eff1e19f-b31b-4b9b-8600-9687c490d9a6/deyb_a_94443_f0003_b.jpg)
Figure 4 Vasoproliferative phase of OIR in dog.
Abbreviation: OIR, oxygen-induced retinopathy.
![Figure 4 Vasoproliferative phase of OIR in dog.](/cms/asset/cddbde25-e403-43ea-badf-8e7628023d7b/deyb_a_94443_f0004_b.jpg)
Figure 5 Intravitreal neovascularization in the dog OIR model.
![Figure 5 Intravitreal neovascularization in the dog OIR model.](/cms/asset/4cb26d77-1afe-45d8-acb1-1519e8b596d8/deyb_a_94443_f0005_b.jpg)
Figure 6 Possible sequence leading to the evolution of inter-anastomosing neovascular networks in the vitreous from a 22-day-old oxygen-treated animal.
![Figure 6 Possible sequence leading to the evolution of inter-anastomosing neovascular networks in the vitreous from a 22-day-old oxygen-treated animal.](/cms/asset/61aec13b-d8e9-44a4-baf3-18b0d8ce0c65/deyb_a_94443_f0006_b.jpg)
Figure 7 Clinical appearance of vascularized membranes in oxygen-treated animals.
![Figure 7 Clinical appearance of vascularized membranes in oxygen-treated animals.](/cms/asset/21358961-d6c3-400c-89ca-45c65ae87f4a/deyb_a_94443_f0007_b.jpg)
Figure 8 Tented vascularized membrane and tractional retinal folds in a 45-day-old oxygen-treated animal.
![Figure 8 Tented vascularized membrane and tractional retinal folds in a 45-day-old oxygen-treated animal.](/cms/asset/a171582c-1f61-4802-9a09-c5872ec23711/deyb_a_94443_f0008_b.jpg)
Figure 9 KDR (VEGFR2) localizationin the canine OIR model.
Abbreviations: vWf, von Willebrand’s factor; KDR, kinase domain receptor; NV, neovascularization.
![Figure 9 KDR (VEGFR2) localizationin the canine OIR model.](/cms/asset/bd823025-f78c-4bab-9b3f-43cb2daae715/deyb_a_94443_f0009_b.jpg)
Figure 10 Effect of anti-KDR on dog OIR.
Abbreviations: OIR, oxygen-induced retinopathy; ADPase, adenosine diphosphatase; KDR, kinase domain receptor.
![Figure 10 Effect of anti-KDR on dog OIR.](/cms/asset/35dd7960-4374-4403-bdd3-0c89f7774ace/deyb_a_94443_f0010_b.jpg)
Figure 11 Effect of anti-KDR on intravitreal and retinal vascular area.
Abbreviation: KDR, kinase domain receptor.
![Figure 11 Effect of anti-KDR on intravitreal and retinal vascular area.](/cms/asset/8a573b2b-7f6e-41dd-bb34-cd44bbb3a1c2/deyb_a_94443_f0011_b.jpg)
Figure 12 Retinal vasculature and intravitreal neovascularization after treatment with VEGF-Trap.
Abbreviation: ADPase, adenosine diphosphatase.
![Figure 12 Retinal vasculature and intravitreal neovascularization after treatment with VEGF-Trap.](/cms/asset/69de6efb-5dc9-4a59-9b5a-1254f85cf5b6/deyb_a_94443_f0012_b.jpg)
Figure 13 Retinal and intravitreal vasculature areas after treatment with VEGF-Trap
Abbreviation: NV, neovascularization.
![Figure 13 Retinal and intravitreal vasculature areas after treatment with VEGF-Trap](/cms/asset/4df5475f-97f2-47f1-81ec-766a896c4af9/deyb_a_94443_f0013_b.jpg)