Figures & data
Figure 1 Structures of select compounds that downregulate Sp protein transcription factors in pancreatic cancer cells.
Abbreviations: CDDO, 2-cyano3,12-dioxooleana-1,9(11)-dien-28-oate; CDODA, 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate; PEITC, phenethyl isothiocyanate; Sp, specificity protein.
Figure 2 BA inhibits pancreatic cancer cell growth (A) and downregulates Sp1, Sp3, and Sp4 after 24 hours treatment (B).
Abbreviations: BA, betulinic acid; Sp, specificity protein.
Figure 3 Proposed schematic for Sp protein downregulation in pancreatic cancer.
Abbreviations: GC, GC-box; miR, microRNA; ROS, reactive oxygen species; Sp, specificity protein.
