Evaluation of antiretroviral effect on mitochondrial DNA depletion among HIV-infected patients in Bali

Figures & data

Table 1 Demographical data and mtDNA:nDNA ratio of the on ART and ART-naïve samples

Characteristics	On ART (N=67)	ART-naïve (N=17)	P-value*
Age (years)	35 (29–42)	30 (27–34)	0.012
Sex
Male (f, %)	44 (66%)	7 (41%)
Female (f, %)	23 (34%)	10 (59%)
Duration of HIV diagnosis (months)	22 (8–36)	1 (1–1)	<0.001
mtDNA:nDNA ratio	1.5 (1.10–2.10)	1.8 (1.30–2.85)	0.121

Notes: Data are reported as median (interquartile range).

* Mann–Whitney rank-sum test.

Abbreviations: ART, antiretroviral therapy; mtDNA, mitochondrial DNA.

Figure 1 Distribution mtDNA:nDNA ratio by duration of treatment.

Abbreviation: mtDNA, mitochondrial DNA.

Table 2 Profile comparison of ZDV-based and TDF-based antiretroviral type

Profile	ZDV-based ART (N=18)	TDF-based ART (N=49)	P-value*
Duration of ART (months)	41 (31–47)	16 (7–30)	<0.001
HIV stage
Non-AIDS (f, %)	2 (11%)	14 (29%)
AIDS (f, %)	16 (89%)	35 (71%)
mtDNA:nDNA ratio	1.2 (1.08–1.98)	1.6 (1.05–2.10)	0.220

Notes: Data are reported as median (interquartile range).

* Mann–Whitney rank-sum test.

Abbreviations: ART, antiretroviral therapy; mtDNA, mitochondrial DNA; TDF, tenofovir; ZDV, zidovudine.