Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study

Figures & data

Table 1 Demographic feature of patients at baseline

Feature	n
N	23
Age	53.1 ± 14.9
Male/female	10/13
BMI (kg/m^2)	20
Hypertension	19
Hyperinsulinemia	18
Dyslipidemia	18
Stage 0/1/2/3	0/14/6/3
Grade 0/1/2/3	0/15/5/3

Figure 1 Body mass index remained unchanged, but changes were seen in serum alanine aminotransferase, thioredoxin, and high-sensitivity C-reactive protein levels in patients with nonalcoholic steatohepatitis before and 12 months following treatment with vitamins C and E.

Abbreviations: BMI, body mass index; ALT, alanine aminotransferase; hs-CRP, high-sensitivity C-reactive protein; TRX, thioredoxin.

Table 2 Steatosis, grading and fibrosis score in NASH patients before and after 12 months of vitamin E and C (n = 10)

Case	Age/gender	Grading of steatosis	Grading of activity	Grading of fibrosis
		Before/after	Before/after	Before/after
1	57/F	2→2	2→1	2→2
2	50/M	3→3	2→1	2→1
3	57/M	2→2	3→1	3→1
4	61/F	1→1	2→0	3→1
5	65/F	3→2	2→1	1→1
6	46/M	3→1	2→1	1→0
7	27/M	3→1	1→1	1→1
8	59/M	1→0	1→0	0→0
9	35/M	2→1	2→1	2→1
10	60/F	2→1	2→1	0→0

Abbreviation: NASH, Nonalcoholic steatohepatitis.

Table 3 Histological interpretation of the effect of vitamin E and C on NASH (A) pretreatment (B) post treatment

Abbreviation: NASH, Nonalcoholic steatohepatitis.

Table 4 Change of 8OHdG expression of the effect of vitamin E and C on NASH (A) pretreatment (B) post treatment

Abbreviation: 8OHdG, 8-hydroxydeoxyguanosine.