Role of ledipasvir/sofosbuvir combination for genotype 1 hepatitis C virus infection

Figures & data

Table 1 Adverse event profile of LDV/SOF

Adverse event, n (%)	8 weeks (n=215)	12 weeks (n=539)	24 weeks (n=326)
Fatigue	45 (21)	116 (22)	79 (24)
Headache	30 (14)	113 (21)	79 (24)
Nausea	15 (7)	61 (11)	36 (11)
Insomnia	11 (5)	41 (8)	30 (9)
Diarrhea	15 (7)	40 (7)	33 (10)
Irritability	3 (1)	22 (4)	21 (6)
Rash	3 (1)	23 (4)	21 (6)
Arthralgia	9 (4)	32 (6)	27 (8)
Cough	3 (1)	18 (3)	21 (6)
Pruritus	2 (1)	21 (4)	10 (3)

Note: Alqahtani SA, Afdhal N, Zeuzem S, et al. Safety and tolerability of ledipasvir/sofosbuvir with and without ribavirin in patients with chronic hepatitis C virus genotype 1 infection: Analysis of phase III ION trials. Hepatology. 2015;62:25–30.³³ With permission from John Wiley and Sons, copyright ©2015.

Abbreviation: LDV/SOF, ledipasvir/sofosbuvir.

AlqahtaniSAAfdhalNZeuzemSSafety and tolerability of ledipasvir/sofosbuvir with and without ribavirin in patients with chronic hepatitis C virus genotype 1 infection: Analysis of phase III ION trialsHepatology201562253025963890

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