Assessing parasite clearance during uncomplicated Plasmodium falciparum infection treated with artesunate monotherapy in Suriname

Figures & data

Table 1 Parasitological assessment

Day 0 parasitemiaa
Geometric mean (95% CI)	5,813
Range	1,201–84,743
IQR range	2,858–10,369
Patient with positive parasitemiaa on day 2 and day 3
Positive parasitemia on day 2 (N=29, %)	18/29 (62)
Positive parasitemia on day 3 (N=30, %)	3/30 (10)
Parasite clearance rate constant (per hour)b
Median	0.13
Range	0.10–0.20
IQR range	0.13–0.14
Slope half-life (hours)b
Median	5.16
Range	3.39–7.14
IQR range	4.84–5.46

Notes:

a Asexual parasites per microliter.

b n=10.

Abbreviations: CI, confidence interval; IQR, interquartile range.

Table 2 Distribution slope half-life

Slope half-life (hours)	Total	Cumulative percentage
0–4	1	10
4–5	2	30
5–6	5	80
6–7	1	90
7–8	1	100

Note: Each interval includes the left-hand side value and not the right-hand side value.

Table 3 Summary of time to clear 50%, 90%, 95%, and 99% of parasitemia (hours)

PCa	Median	Range	IQR range
PC50	8.86	4.49–15.16	7.21–10.69
PC90	21.04	12.53–27.59	18.45–25.70
PC95	26.29	15.92–34.73	23.29–31.49
PC99	38.47	23.78–51.31	34.52–43.85

Note:

a Parasite clearance time of, respectively, 50%, 90%, 95%, and 99% of initial density.

Abbreviation: IQR, interquartile range.

Figure 1 Parasite clearance curves (n=10).

Notes: Black dots represent measurements used in the estimation of clearance rate. Red dots represent outliers excluded from calculation. Green dots represent measurements below the level of detection.

Figure 2 Distribution of parasite half-lives.