Plasmodium knowlesi malaria: current research perspectives

Figures & data

Table 1 Selection pressure on proteins of P. knowlesi involved in erythrocyte invasion

Proteins	Origin of analyzed samples	Selection pressure in P. knowlesi	References
Duffy binding protein alpha region II	Clinical samples from Peninsular Malaysia and Borneo	Purifying	73, 77
Normocyte binding protein Xa	Clinical samples from Peninsular Malaysia and Borneo	Purifying	74
Apical membrane antigen-1
Whole protein	Clinical samples from Sabah	Purifying	75
	Clinical samples from Sarawak	No evidence of diversifying selection	85
Domain I	Clinical samples from Peninsular Malaysia	Purifying	80
Merozoite surface protein 3 (C-terminal)	Clinical samples from Peninsular Malaysia	Purifying	76
Circumsporozoite protein (nonrepeat regions)	Clinical samples from Peninsular Malaysia and samples from long-tailed macaques	Purifying; Slight positive at the C-terminal Th2R/Th3R region	78
Gamma protein region II	Clinical samples from Peninsular Malaysia and Borneo	Purifying	79
Merozoite surface protein 1
Conserved domains	Clinical samples and samples from pig-tailed macaques and long-tailed macaques in Thailand	Purifying	81
MSP-142	Clinical samples from Selangor and Sabah	Purifying	83
Rhoptry-associated protein 1	Clinical samples from Peninsular Malaysia	Purifying	82