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Infection and Drug Resistance Volume 11, 2018 - Issue
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Original Research

Detection of common mobile genetic elements and genotyping of multidrug-resistant Gram-negative bacilli in blood specimens from septicemia patients in southern China

Yongyu RuiLaboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
,
Wengting LuLaboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
,
Si LiLaboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
,
Cancan ChengLaboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
,
Jingjing SunLaboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
&
Qiu YangLaboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
Pages 1741-1750 | Published online: 12 Oct 2018

Figures & data

Table 1 Number of common mobile genetic elements in multidrug-resistant Gram-negative bacilli

Table 2 Characterization of class 1 integron in multidrug-resistant Gram-negative bacilli

Figure 1 Twenty-seven distinct class 1 integron resistance gene arrangements.

Notes: Integrase is represented by orange boxes. qacEΔ1/sul1 is represented by gray boxes.
Figure 1 Twenty-seven distinct class 1 integron resistance gene arrangements.

Table 3 Characterization of ISCR1-linked gene in multidrug-resistant Gram-negative bacilli

Figure 2 Twelve distinct ISCR1-linked resistance gene arrangements.

Notes: ISCR1 is represented by red boxes. #Dehydrogenase/reductase; *first reported.
Abbreviations: GST, glutathione-S-transferase; ISCR1, insertion sequence common region 1.
Figure 2 Twelve distinct ISCR1-linked resistance gene arrangements.

Figure 3 Seven distinct structures connecting the variable regions of the complex class 1 integron structures.

Notes: The types of structures were marked from A to G. Integrase is represented by orange boxes; the qacEΔ1/sul1 is represented by gray boxes; ISCR1 is represented by red boxes. *First reported.
Abbreviations: GST, glutathione-S-transferase; ISCR1, insertion sequence common region 1.
Figure 3 Seven distinct structures connecting the variable regions of the complex class 1 integron structures.

Figure 4 ERIC-PCR profile of (A) 90 ESBL-producing Escherichia coli, (B) 98 ESBL-producing Klebsiella pneumoniae, (C) 44 carbapenem-resistant Acinetobacter baumannii and (D) 40 carbapenem-resistant Pseudomonas aeruginosa.

Abbreviation: ERIC, enterobacterial repetitive intergenic consensus.
Figure 4 ERIC-PCR profile of (A) 90 ESBL-producing Escherichia coli, (B) 98 ESBL-producing Klebsiella pneumoniae, (C) 44 carbapenem-resistant Acinetobacter baumannii and (D) 40 carbapenem-resistant Pseudomonas aeruginosa.

Table S1 Primers used in this study

Table S2 Susceptibility (SIR) pattern of dominating isolates of multidrug-resistant Gram-negative bacilli

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