A novel plasmid carrying carbapenem-resistant gene bla_KPC-2 in Pseudomonas aeruginosa

Figures & data

Figure 1 Timeline of antimicrobial treatment and bacterial isolation of the patient. Colored text and bars represent the source that the bacterial species was isolated from.

Abbreviations: CR, carbapenem-resistant; PA, P. aeruginosa; SM, Stenotrophomonas maltophilia; AB, Acinetobacter baumannii; CA, Candida albicans; LEV, levofloxacin; MEM, meropenem; TEC, teicoplanin; CIP, ciprofloxacin.

Figure 2 Comparison of the genetic organization between pPA1011 and p14057. Genes are denoted by arrows. Shading denotes regions of homology (>90% nucleotide identity). The accession number of p14057 for reference is KY296095.

Figure 3 Schematic representation of the genetic environment surrounding the bla_KPC-2 gene on pPA1011. Genes and their corresponding transcription orientations are indicated by colored arrows. Shading denotes regions of homology (100% nucleotide identity). The accession numbers of pKP048, p14057 and Tn4401 for reference are KT362706, KY296095 and FJ628167, respectively. The sequence of pE1 from Copyright©2014. American Society for Microbiology. Adapted from Cai JC, Zhang R, Hu YY, Zhou HW, Chen GX. Emergence of Escherichia coli sequence type 131 isolates producing KPC-2 carbapenemase in China. Antimicrob Agents Chemother. 2014;58(2):1146–1152.¹³

Cai JC, Zhang R, Hu YY, Zhou HW, Chen GX. Emergence of Escherichia coli sequence type 131 isolates producing KPC-2 carbapenemase in China. Antimicrob Agents Chemother. 2014;58(2):1146–1152. doi:10.1128/AAC.00912-1324323475

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