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Review

Safety and efficacy of liposomal amphotericin B for the empirical therapy of invasive fungal infections in immunocompromised patients

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Pages 9-16 | Published online: 11 Jan 2012

Figures & data

Figure 1 Current strategies for the management of IFI in high-risk patients.

Notes: *High-resolution computed tomography scan of the lungs showing new ≥1 cm single or multiple nodules with or without halo sign, lobar consolidation, wedge-shaped consolidative infarct; **classic example: patients with proglonged and profound neutropenia after intense chemotherapy for hematologic malignancy.

Abbreviations: GM, serum Galactomannan; IFI, invasive fungal infection; PCR, polymerase chain reaction.

Figure 1 Current strategies for the management of IFI in high-risk patients.Notes: *High-resolution computed tomography scan of the lungs showing new ≥1 cm single or multiple nodules with or without halo sign, lobar consolidation, wedge-shaped consolidative infarct; **classic example: patients with proglonged and profound neutropenia after intense chemotherapy for hematologic malignancy.Abbreviations: GM, serum Galactomannan; IFI, invasive fungal infection; PCR, polymerase chain reaction.

Table 1 US Food and Drug Administration-approved indication of antifungal agents for the management of IFIs

Table 2 Summary of clinical trials comparing efficacy and safety of liposomal amphotericin B with other antifungal agents for empirical antifungal therapy in patients with neutropenia