Treatment of dengue fever

Figures & data

Table 1 Summary of evidence of benefit for available intervention in dengue infection

Intervention	Conclusion
Choice of intravenous fluid	RCTs show no benefit of colloids over crystalloids,^Citation17^–^Citation19 although a trend towards benefit is seen with colloids over crystalloids in severe cases
Rate of fluid infusion	No evidence available, regimens based on experience of centers treating large numbers of cases
Transfusion of blood products	Small RCT suggests that fresh frozen plasma may increase platelet counts^Citation21
Nasal CPAP	RCT shows benefit in terms of improvement of hypoxemia and reduction of the need for ventilation in patients with dengue and acute respiratory failure^Citation33
Carbazochrome sodium sulfonate	RCT shows no evidence of benefit, but underpowered^Citation35
Corticosteroids	Systematic review of RCTs shows no benefit, but available RCT evidence is from studies performed > 20 years ago;^Citation25,Citation26 case series provide limited evidence of possible benefit in severe dengue^Citation28
Immunoglobulins	Single RCT shows no benefit for thrombocytopenia;^54 no evidence available for other manifestations^55

Abbreviations: RCT, randomized controlled trial; CPAP, continuous positive airways pressure.

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