Helicobacter pylori, Endoscopic, And Histologic Features Among Kidney Transplant Candidates In Southern Iran

Figures & data

Table 1 Clinical And Demographic Characteristics Of The Participants Among Kidney Transplant Candidates (n=293)

Characteristics		Frequency (%)
Mean age (years)	47.37±14.15
Gender
Male		183 (62.5)
Female		110 (37.5)
Age distribution (years)	<30	44 (15.02)
	30–50	111 (37.88)
	>50	138 (47.10)
Etiology of chronic kidney disease
Hypertension		115 (39.25)
Diabetes mellitus		54 (18.43)
Nephrotic and nephritic syndrome		46 (15.70)
Urinary Tract Obstruction		28 (9.56)
Others		12 (4.09)
Unknown		38 (12.97)
Anemia (Hemoglobin<12)		61.7
Cigarette smoking		4.1
BMI (Kg/m^2)	23.74±3.85
Heavy drinking		0
Dyspepsia symptoms		65 (22.18)

Table 2 The Comparison Of Laboratory Data Between Positive And Negative helicobacter pylori (H. pylori) Among Kidney Transplant Candidates

Laboratory Data Variables*	Positive H. pylori (n=146)	Negative H. pylori (n=147)	P-value
Bloor urea nitrogen (mg/dL)	76.5 (6.7)	75.7 (5.9)	0.28
Serum creatinine (mg/dL)	7.0 (0.4)	6.9 (0.7)	0.14
Serum potassium (mEq/L)	5.3 (0.8)	5.4 (0.9)	0.32
Serum calcium (mg/dL)	8.5 (1.5)	8.4 (1.3)	0.54
Serum aspartate transaminase (IU/L)	19.8 (12.4)	18.6 (13.5)	0.43
Serum alanine transaminase (IU/L)	18.2 (11.3)	19.2 (12.6)	0.48
Serum albumin (mg/dL)	4.2 (0.5)	4.1 (0.8)	0.20
Serum total cholesterol (mg/dL)	181 (35.4)	172 (64.3)	0.14
Serum triglyceride (mg/dL)	164 (70.2)	153 (61.7)	0.16

Notes: *Mean (standard deviation); Test: Independent t-test.

Table 3 The Association Between Helicobacter pylori (H. pylori) Infection And Endoscopic Findings Among Kidney Transplant Candidates (n=293)

Endoscopic Findings	Positive H. pylori	Negative H. pylori	P-value
Esophagus	151 (%)	142 (%)
Normal	99 (65.56)	94 (66.20)	0.91
Gastroesophageal reflux disease	50 (33.11)	44 (30.98)	0.70
Others	2 (1.33)	4 (2.82)	0.37
Stomach	147 (%)	146 (%)
Normal	40 (27.21)	50 (34.25)	0.19
Abnormal non-ulcerative	90 (61.22)	89 (60.96)	0.96
Ulcerative	17 (11.57)	7 (4.79)	0.03
Duodenum	147 (%)	146 (%)
Normal	89 (60.54)	92 (63.02)	0.66
Abnormal non-ulcerative	37 (25.17)	41(28.08)	0.57
Ulcerative	21 (14.29)	13 (8.90)	0.15

Notes: Test: Chi-squared test.

Table 4 The Association Between Gastric Endoscopic Findings And Histology Of Gastric Biopsy Samples Among Kidney Transplant Candidates (n=293)

Histology Of Gastric Biopsy Samples*	Normal Endoscopy (%)	Abnormal Endoscopy** (%)	P-value
Normal/non-significant	26 (29.21)	36 (17.65)	0.03
Inflammation	63 (70.79)	150 (73.53)	0.63
Pre-malignant lesions	0	18 (8.82)	<0.01

Notes: Test: Chi-squared test. *Endoscopic biopsies of abnormal gastric mucosa as well as random biopsies in all participants with normal mucosa. **Abnormal Endoscopy including ulcerative lesions or abnormal non-ulcerative lesions.

Table 5 The Association Between Helicobacter pylori (H. pylori) Infection And Histology Of Gastric Biopsy Samples Among Kidney Transplant Candidates (n=293)

Histology Of Gastric Biopsy Samples*	Positive H. pylori (%)	Negative H. pylori (%)	P-value
Normal/non-significant	4 (2.74)	58 (39.46)	<0.01
Inflammation	133 (91.10)	80 (54.42)	<0.01
Premalignant lesions	9 (6.16)	9 (6.12)	0.99

Notes: Test: Chi-squared test. *Endoscopic biopsies of abnormal gastric mucosa as well as random biopsies in all participants with normal mucosa.