Characterization of Phenotypic and Genotypic Traits of Klebsiella pneumoniae from Lung Cancer Patients with Respiratory Infection

Figures & data

Figure 1 Flowchart diagram of samples collection.

Abbreviations: KP, Klebsiella pneumoniae; SA, Staphylococcus aureus; AB, Acinetobacter baumannii.

Table 1 Antibiotic Susceptibility Profiles of K. pneumoniae

Antibiotic	Range	MIC50	MIC90	S%	I%	R%
AMK	1->128	2	4	94.6%	0	5.4%
GEN	0.25->512	0.5	64	78.4%	0	21.6%
AMC	2/1->256/128	16/8	64/32	48.7%	2.7%	48.6%
ATM	0.03->64	0.5	64	51.4%	0	48.6%
CAZ	0.06->64	2	64	56.8%	8.1%	35.1%
CIP	0.15->128	16	128	48.6%	0	51.4%
FOS	8–256	16	32	94.6%	2.7%	2.7%
ETP	0.004->4	0.06	0.5	91.9%	2.7%	5.4%
IMP	0.06->8	0.25	0.5	94.6%	0	5.4%
MEM	0.015->8	0.03	0.06	94.6%	0	5.4%
TET	0.5–256	128	256	35.1%	0	64.9%
TGC	0.06–8	0.5	2	91.9%	0	8.1%
PB	0.125–64	1	8	68.9%	0	31.1%

Abbreviations: AMK, Amikacin; GEN, Gentamicin; AMC, Amoxicillin-clavulanate; ATM, Aztreonam; CAZ, Ceftazidime; CIP, Ciprofloxacin; FOS, Fosfomycin; ETP, Ertapenem; IMP, Imipenem; MEM, Meropenem; TET, Tetracycline; TGC, Tigecycline; PB, Polymyxin B.

Figure 2 PFGE dendrogram of K. pneumoniae strains.

Notes: The similarity percentage of profiles was calculated by the Dice coefficient.

Abbreviations: M, multidrug-resistant strain; B, ESBL gene-harboring strain; T, tet (A) gene variant-harboring strain; P, polymyxin B-resistant strain; CRKP, carbapenem-resistant K. pneumoniae.

Figure 3 Virulence potential of different K. pneumoniae strains.

Notes: Virulence potential of K. pneumoniae strains in a G. mellonella infection model. The effect of 1×10⁵ colony-forming units of each K. pneumoniae strain on survival was assessed in G. mellonella.