Multi-Drug Resistant Escherichia coli Causing Early-Onset Neonatal Sepsis – a Single Center Experience from China

Figures & data

Table 1 Distribution of Pathogens of EOS in 2002–2008 and 2012–2018

Pathogens	2002–2008 (n = 65)	2012–2018 (n = 98)
Gram-positive organisms
GBS	0 (0%)	26 (26.5%)*
CoNS	13 (20.0%)	12 (12.2%)
Enterococcus	6 (9.2%)	11 (11.2%)
Staphylococcus aureus	2 (3.1%)	6 (6.1%)
Listeria monocytogenes	1 (1.5%)	3 (3.1%)
Other	8 (12.3%)	8 (8.2%)
Gram-negative organisms
E coli	21 (32.3%)	26 (26.5%)
Klebsiella	5 (7.7%)	2 (2.0%)
Other	9 (13.8%)	4 (4.1%)

Notes: *Χ2 = 20.518, P < 0.001.

Table 2 General Characteristics of Patients with Early-Onset E. coli Sepsis

	2002–2008 (n = 21)	2012–2018 (n = 26)	P-value
Male gender	14 (66.7%)	15 (57.75%)	N.S.
Gestational age (weeks)	39.3 ± 1.9	35.8± 4.6	0.001
<37 weeks	2 (9.5%)	13 (50.0%)	0.003
Birth weight (gm)	3125 ± 563	2648 ± 960	0.040
<2500 gm	2 (9.5%)	12 (46.2%)	0.006
Maternal age (years)	26.8 ± 5.2	30.0 ± 5.7	0.047
Vaginal delivery	20 (95.2%)	22 (84.6%)	N.S.
PROM>18hrs	3 (14.3%)	10 (38.5%)	N.S.
Intrapartum fever	1 (4.8%)	5 (19.2%)	N.S.
Antepartum antibiotic	0 (0%)	9 (34.65%)	0.009
Home delivery	4 (19.0%)	1 (3.8%)	N.S.
Respiratory distress	4 (19.0%)	9 (34.6%)	N.S.
Shock	2 (9.5%)	2 (7.7%)	N.S.
Meningitis	4 (19.0%)	3 (11.5%)	N.S.
Death	2 (9.5%)	4 (15.4%)	N.S.

Note: *P < 0.05.

Abbreviation: NS, not significant.

Figure 1 Antimicrobial susceptibility of all isolated E. coli in 2002–2008 and 2012–2018. *P < 0.05.

Figure 2 Antimicrobial susceptibility of all isolated E. coli from term and preterm infants.