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Infection and Drug Resistance Volume 13, 2020 - Issue
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Original Research

Whole-Genome Analysis of Two Copies of blaNDM-1 Gene Carrying Acinetobacter johnsonii Strain Acsw19 Isolated from Sichuan, China

Lingtong Tang1 Department of Clinical Laboratory, The People’s Hospital of Gao County, Sichuan644000, People’s Republic of China;2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China
,
Wei Shen2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China;3 Department of Clinical Laboratory, The First People’s Hospital of Yibin, Yibin644000, Sichuan, People’s Republic of China
,
Zhikun Zhang2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China
,
Jingping Zhang2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China
,
Guangxi Wang2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China
,
Li Xiang2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China
,
Junping She2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China
,
Xiaoyan Hu2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China
,
Guoyuan Zou4 Institute of Plant Nutrition and Resources, Beijing Academy of Agriculture and Forestry Science, Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1333-7422
ORCID Icon,
Baoli Zhu5 Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-5326-9503
ORCID Icon &
Yingshun Zhou2 Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 855-865 | Published online: 23 Mar 2020

Figures & data

Table 1 Characteristic of the Whole Genome of Acinetobacter johnsonii Acsw19

Table 2 Distribution of the Resistance Genes in Acinetobacter johnsonii Strain Acsw19

Figure 1 Molecular phylogenetic analysis by maximum likelihood method with 1000 bootstraps of OXA-211 like (a novel variant of OXA-211 family) with the six Class D β-lactamases (CHDLs) OXA family (OXA-23, OXA-24/40, OXA-235/134, OXA-58, OXA-48, OXA-211) representative sequences retrieved from GenBank database. The black triangle was indicated the gene which was found in this study.

Figure 1 Molecular phylogenetic analysis by maximum likelihood method with 1000 bootstraps of OXA-211 like (a novel variant of OXA-211 family) with the six Class D β-lactamases (CHDLs) OXA family (OXA-23, OXA-24/40, OXA-235/134, OXA-58, OXA-48, OXA-211) representative sequences retrieved from GenBank database. The black triangle was indicated the gene which was found in this study.

Figure 2 Molecular phylogenetic analysis by maximum likelihood method with 1000 bootstraps of CmlA/FloR family chloramphenicol efflux MFS (cmlB1-like) with the eight CmlA/FloR family chloramphenicol efflux MFS representative sequences retrieved from GenBank database. The black triangle was indicated the gene which was found in this study.

Figure 2 Molecular phylogenetic analysis by maximum likelihood method with 1000 bootstraps of CmlA/FloR family chloramphenicol efflux MFS (cmlB1-like) with the eight CmlA/FloR family chloramphenicol efflux MFS representative sequences retrieved from GenBank database. The black triangle was indicated the gene which was found in this study.

Figure 3 Schematic map of the genetic context of resistance gene regions in pAcSW19-2. The resistance genes are indicated by red arrows, the mobile genes are indicated by the green arrows and other function genes are indicated by the purple arrows. Gray areas between open reading frames (ORFs) denote nucleotide identities with the similarity context.

Figure 3 Schematic map of the genetic context of resistance gene regions in pAcSW19-2. The resistance genes are indicated by red arrows, the mobile genes are indicated by the green arrows and other function genes are indicated by the purple arrows. Gray areas between open reading frames (ORFs) denote nucleotide identities with the similarity context.

Table 3 Overall Features of the Acinetobacter johnsonii Strain Acsw19 Genomic Islands

Figure 4 Schematic map of the genetic context of the GI_Acsw19-11. The resistance genes are indicated by red arrows, the mobile genes are indicated by the green arrows and other function genes are indicated by the purple arrows. Gray areas between open reading frames (ORFs) denote nucleotide identities with the similarity context.

Figure 4 Schematic map of the genetic context of the GI_Acsw19-11. The resistance genes are indicated by red arrows, the mobile genes are indicated by the green arrows and other function genes are indicated by the purple arrows. Gray areas between open reading frames (ORFs) denote nucleotide identities with the similarity context.

Figure 5 Schematic map of the genetic context of the GI_Acsw19-2. The resistance genes are indicated by red arrows, the mobile genes are indicated by the green arrows and other function genes are indicated by the purple arrows. Gray areas between open reading frames (ORFs) denote nucleotide identities with the similarity context.

Figure 5 Schematic map of the genetic context of the GI_Acsw19-2. The resistance genes are indicated by red arrows, the mobile genes are indicated by the green arrows and other function genes are indicated by the purple arrows. Gray areas between open reading frames (ORFs) denote nucleotide identities with the similarity context.

Table 4 Overall Features of the Acinetobacter johnsonii Strain Acsw19 Prophage

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