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Original Research

A Simple Scoring Algorithm That Predicts Abscesses in Adults with Community-Onset Klebsiella pneumoniae Bacteremia: Hypermucoviscosity Matters

ORCID Icon, , , , ORCID Icon & ORCID Icon
Pages 1045-1055 | Published online: 14 Apr 2020

Figures & data

Figure 1 Schematic flow chart.

Figure 1 Schematic flow chart.

Table 1 Clinical Characteristics of Adults with Community-Onset Monomicrobial K. pneumoniae Bacteremia, Categorized by the Presence or Absence of Abscesses

Figure 2 Microbiological characteristics of K. pneumoniae isolates causing community-onset bacteremia with or without abscesses (A) and with a hepatic abscess or extra-hepatic abscess (B).

Abbreviation: HMV, hypermucoviscosity.

Figure 2 Microbiological characteristics of K. pneumoniae isolates causing community-onset bacteremia with or without abscesses (A) and with a hepatic abscess or extra-hepatic abscess (B).Abbreviation: HMV, hypermucoviscosity.

Table 2 Multivariate Analysis of Risk Factors for Abscess Formation Among Community-Onset Monomicrobial K. pneumoniae Bacteremia

Table 3 The Sensitivity, Specificity, Predictive Value, and Likelihood Ratio of the CoKPBAS (Model 1) for Abscess Occurrences in Various Cut-Off Points

Figure 3 Receiver operating characteristic curves of three models of K. pneumoniae abscess scoring to predict abscess formation in community-onset monomicrobial K. pneumoniae bacteremia. The area under the ROC curve is 0.83 (95% confidence interval [CI], 0.77–0.88; P<0.001) in model 1, 0.80 (95% CI, 0.74–0.86; P<0.001) in model 2, and 0.77 (95% CI, 0.71–0.83; P<0.001) in model 3.

Figure 3 Receiver operating characteristic curves of three models of K. pneumoniae abscess scoring to predict abscess formation in community-onset monomicrobial K. pneumoniae bacteremia. The area under the ROC curve is 0.83 (95% confidence interval [CI], 0.77–0.88; P<0.001) in model 1, 0.80 (95% CI, 0.74–0.86; P<0.001) in model 2, and 0.77 (95% CI, 0.71–0.83; P<0.001) in model 3.

Table 4 Infection Sources, Clinical Management, and Outcome of Adults with Community-Onset Monomicrobial K. pneumoniae Bacteremia, Categorized by the Presence or Absence of Abscessesa

Table 5 Hypermucoviscosity and Risk Factors of 28-Day Crude Mortality