Disk-Diffusion Testing Is an Inappropriate Screening Tool for Cephalosporin-Resistant Gonorrhoea Strains in Clinical Practice in China

Figures & data

Table 1 Comparison of Agar-Dilution Method and KB Test for Ceftriaxone

MIC (μg/mL)	Diameters of Inhibition Zone by KB Test (mm)																																							Total
	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	58	60
0.008		1		1		2	1	3	6	4	11	7	7	8	8	26	21	15	21	16	67	19	53	11	19	20	17	4	15	3	24	3	3		2	3	4	1		426
0.016			1				1	1	2	1	3		5	3	1	18	18	7	25	6	35	5	17	5	13	12	4	2	4	1	5					1	1	1		198
0.031	1			1		1	1		3	3	10	3	5	3	4	27	20	9	21	13	57	8	24	10	14	23	14	1	5		10	1	1			4			1	298
0.062				1	1	4	2		2		8	1	8	4	6	39	19	10	17	10	49	7	16	3	10	15	6	1	7		4		2	1	1	1				255
0.125				1			1	1			8	2		1	6	12	5	2	7	5	18		4	2	2	3	2		1		1									84
0.250											1		2	1	1	5	2	2	2		7		1	2		1					2									29
0.500											1	1			1	4			2		1			2		2														14
1.000												1					1																							2
Total	1	1	1	4	1	7	6	5	13	8	42	15	27	20	27	131	86	45	95	50	234	39	115	35	58	76	43	8	32	4	46	4	6	1	3	9	5	2	1	1,306

Notes: Each number in bold type represents the number of isolates with the same susceptibility on the agar-dilution method and the KB test for ceftriaxone (Pearson’s correlation coefficient — r=0.21). All test results of N. gonorrhoeae for ceftriaxone by the agar-dilution AST method and the KB test interpreted as insusceptible or usceptible are marked in bold.

Table 2 Comparison of Agar-Dilution Method and KB Test for Cefixime

MIC (μg/mL)	Diameters of Inhibition Zone by KB Test (mm)
	16	17	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	52	54	56	Total
0.008		1				1			2		2	9	4	12	8	15	6	9	28	25	16	27	8	36	4	22	5	12	10	8	1	5		5	2	1	1	285
0.016								1	5	1	1	3	4	11	12	11	6	7	14	19	6	20	12	37	3	7	5	3	9	2			1	4				204
0.031			1	2	1		1		3	1	2	5	6	12	13	17	13	8	27	21	12	17	9	35	7	12	1	2	7	5		3		1				244
0.063							1		2	3	2	3	2	12	18	15	14	10	40	21	11	31	7	39	1	12	3	4	8	4		2		2				267
0.125			1	2		1		2	3	4	5	8	5	11	9	6	6	17	27	8	8	13	3	25	1	3	1	3	2	1		1						176
0.250	1			1		2	1	3	1	2	1	1	1	7	8	7	3	2	12	5	1	5		7	3				2									76
0.500							1	1	1	1		1	1	5	7	5	5	3	1			2			2									1				37
1.000						1			1	1	1			1	1	1			1						1	1	1											11
2.000						1									2	1	1																					5
Total	1	1	2	5	1	6	4	7	18	13	14	30	23	71	78	78	54	56	150	99	54	115	39	179	22	57	16	24	38	20	1	11	1	13	2	1	1	1,305

Notes: Each number in bold type represents the number of isolates with the same susceptibility on the agar-dilution method and the KB test for cefixime (Pearson’s correlation coefficient — r=0.21). All test results of N. gonorrhoeae for cefixime by the agardilution AST method and the KB test interpreted as insusceptible or susceptible are marked in bold.