Microbiological Characteristics of Carbapenem-Resistant Enterobacteriaceae Clinical Isolates Collected from County Hospitals

Figures & data

Table 1 Resistance and Susceptibility of All the Strains to Antimicrobial Agents

Antimicrobial Agent	%R	%S	MIC50	MIC90	MIC Range
Piperacillin	97.7	2.3	>256	>256	≤2–>256
Cefoperazone-sulbactam	93	4.7	>128	>128	≤1–>128
Piperacillin-tazobactam	95.3	2.3	>256	>256	≤2–>256
Cefazolin	100	0	>32	>32	>32–>32
Cefuroxime	100	0	>64	>64	32–>64
Ceftazidime	93	4.7	>32	>32	≤0.25–>32
Cefepime	97.7	2.3	>32	>32	≤0.25–>32
Cefotaxime	95.3	2.3	>32	>32	≤0.25–>32
Cefmetazole	79.1	18.6	>64	>64	4–>64
Moxalactam	76.7	9.3	>64	>64	≤0.5–>64
Aztreonam	93	7	>128	>128	≤1–>128
Ertapenem	97.7	2.3	>32	>32	≤0.25–>32
Imipenem	93	0	>16	>16	2–>16
Meropenem	93	7	>16	>16	≤0.125–>16
Amikacin	51.2	46.5	>128	>128	2–>128
Gentamicin	67.4	27.9	>128	>128	≤1–>128
Ciprofloxacin	81.4	18.6	>8	>8	≤0.06–>8
Levofloxacin	67.4	23.3	16	>16	≤0.125–>16
Trimethoprim-sulfamethoxazole	53.5	46.5	>32	>32	≤0.25–>32
Colistin	7.0	93	0.25	0.5	≤0.125–>16
Nitrofurantoin	67.4	18.6	128	256	8–>128
Tigecycline	9.7	90.3	0.5	1	0.25–2

Abbreviations: R, resistance; S, susceptible.

Table 2 Distribution of Gene Type of 43 Strains of CRE

Gene Type	Strains (Number)	MIC Range (mg/L)				PFGE	MLST
		Imipenem	Meropenem	Colistin	Tigecycline
KPC-2+CTX-M+14+SHV-11	K. pneumoniae (8)	8–>16	8–>16	<=0.125–1	0.25–1	A1,A2,B,D,G3,H,J1(2)	ST11(8)
KPC-2+CTX-M-14+SHV-12	K. pneumoniae (6)	>16	>16	0.25–0.5	0.25–2	A3(2),A4,B,G2,M	ST11(6)
KPC-2+CTX-M-15+CTX-M-14+SHV-11	K. pneumoniae (3)	8–>16	16–>16	0.25–0.5	0.25–1	A1,D,J2	ST11(3)
KPC-2	K. pneumoniae (3)	>16	8->16	<=0.125–>16	0.25-2	O(3)	ST116(1)
KPC-2+SHV-11	K. pneumoniae (2)	16–>16	>16	0.25	0.5–1	C,I	ST11(2)
NDM-4	E. cloacae (2)	4-4	8-8	0.25	0.25–0.5	-	-
CTX-M-55	K. pneumoniae (1)	32	>16	0.25	0.25	K	ST2536
DHA-1	M. morganii (1)	4	<=0.125	>16	1	-	-
CMY-2	E. coli (1)	2	1	0.25	0.5	S	ST58
KPC-2+CTX-M-55	K. pneumoniae (1)	>16	>16	0.25	0.5	K	ST2338
KPC-2+SHV-2a	K. pneumoniae (1)	>16	>16	0.25	2	G1	ST2245
KPC-2+CTX-M-15+SHV-LEN	K. pneumoniae (1)	>16	>16	0.25	0.25	F	ST39
KPC-2+CTX-M-14+SHV-31	K. pneumoniae (1)	>16	>16	0.25	0.5	H	ST11
KPC-2+CTX-M-15+SHV-28	K. pneumoniae (1)	8	8	0.25	0.25	E	ST15
KPC-2+CTX-M-15+CTX-M-14+SHV-12	K. pneumoniae (1)	>16	>16	0.25	0.25	G1	ST667
KPC-2+NDM-1+SHV-12	C. freundii (1)	8	8	0.5	1	-	-
SHV-12	E. coli (1)	4	1	0.5	0.25	Q	ST506
NDM-1	E. cloacae (1)	4	16	0.25	0.25	-	-
NDM-1+SHV-12	E. cloacae (1)	2	4	<0.125	0.25	-	-
NDM-5+CTX-M-55+SHV-12	E. coli (1)	>16	>16	0.5	0.5	R	ST2
NDM-16+SHV-12	K. pneumoniae (1)	8	16	0.25	0.5	N	ST705
NDM-16+CTX-M-15+SHV-LEN	K. pneumoniae (1)	8	16	0.25	0.5	L	ST39
IMP-4+CTX-M-15+SHV-11	K. pneumoniae (1)	2	4	0.25	0.25	L	ST1110
Negative	K. pneumoniae (1), S. marcescen (1)	>16	16->16	0.5->16	0.25–2	-	-

Figure 1 DNA fingerprints and β-lactamases distribution of K. pneumoniae isolates (A) and E. coli isolates (B).