https://orcid.org/0000-0003-4646-5949
Figures & data
Table 1 Primer Sequences for the Amplification of the Drug Resistance Gene of H. pylori
Figure 1 Flowchart of this study.
Table 2 Spearman Correlation Between Phenotype and Genotype of 65 H. pylori Strains
Table 3 Gene Mutations Related to CLA and LEV Resistance of the 112 H. pylori Positive Samples
Figure 2 Comparison of 23S rRNA allele and gyrA allele sequences of H. pylori. (A) 23S rRNA allele sequences of H. pylori. Sequence alignment showed that 23S rRNA allele was in the V region. Part of the RNA sequence of 23S rRNA V region shows the allele sequence found in different H. pylori clinical isolates. Compared with ATCC 26695, the mutant was 2143 adenine-guanine mutation. The point mutation has been marked black. (B) gyrA allele sequences of H. pylori. Sequence alignment showed that the amino acid sequence of gyrA was in QRDRs. Compared with ATCC 26695, mutant N87K was 87 asparagine-lysine mutations, mutant D91G was 91 aspartic acid-glycine mutations, and mutant D91Y was 91 aspartic acid-tyrosine mutations. The point mutation has been marked black.
Table 4 18 H. pylori Strains with MIC Resistance to Both CLA and LEV and the Corresponding Mutations
Table 5 Seven Strains with Discordant Phenotype to Genotype Resistance to CLA and LEV