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Review

The Impact of Gut Microbiota Disorders on the Blood–Brain Barrier

ORCID Icon, ORCID Icon, , & ORCID Icon
Pages 3351-3363 | Published online: 29 Sep 2020

Figures & data

Figure 1 The blood–brain barrier is composed of brain microvascular endothelial cells, pericytes, the continuous basement membrane and the perivascular feet of astrocytes, preventing the entry of harmful substances into the brain tissue. The blood–brain barrier interacts with extracellular matrices, neurons, and microglia, forming neurovascular units, which regulate the structure and function of the blood–brain barrier.

Figure 1 The blood–brain barrier is composed of brain microvascular endothelial cells, pericytes, the continuous basement membrane and the perivascular feet of astrocytes, preventing the entry of harmful substances into the brain tissue. The blood–brain barrier interacts with extracellular matrices, neurons, and microglia, forming neurovascular units, which regulate the structure and function of the blood–brain barrier.

Figure 2 Pathways of the effects of gut microbiota on the blood–brain barrier. The gut microbiota can affect the structure and function of the blood–brain barrier through various pathways, such as their metabolites, and the nervous, endocrine, and immune systems.

Figure 2 Pathways of the effects of gut microbiota on the blood–brain barrier. The gut microbiota can affect the structure and function of the blood–brain barrier through various pathways, such as their metabolites, and the nervous, endocrine, and immune systems.