Advantages and Challenges of Tailored Regimens for Drug-Resistant Tuberculosis: A StopTB Italia Look into the Future

Figures & data

Table 1 Proposed Therapeutic Drug Monitoring in DR-TB Tailored Regimens

Compounds	Dosage	Time for Sampling	Desirable TDM Level (mg/L)	Reason
Isoniazid	300 mg die	2 hours post dose on empty stomach (every follow-up visit or in case of toxicity)	3–6	E/T
Rifampicin	600 mg die	2 hours post dose on empty stomach (every follow-up visit or in case of toxicity)	8–15	E/T
Pyrazinamide	25 mg/Kg (max 2500 mg) die	2 hours post dose on full or empty stomach (every follow-up visit or in case of toxicity)	20–60	E/T
Ethambutol	25 mg/Kg (max 1600 mg) die	2 and 6 hours post dose on full or empty stomach (every follow-up visit or in case of toxicity)	20–60	E
Levofloxacin	max 1000 mg die	2 hours post dose on full or empty stomach (every follow-up visit or in case of toxicity)	8–12	E
Moxifloxacin	max 800 mg die	2 hours post dose on full or empty stomach (every follow-up visit or in case of toxicity)	3–5	E
Clofazimine	max 100 mg die	2 hours post dose on full or empty stomach (every follow-up visit or in case of toxicity)	0.5–4	T
Linezolid	max 1200 mg die	immediately before the dose (28 days or in case of toxicity)	2–7	T
Meropenem c.i.	max 6 g die	during administration (every week)	8–12	E
Bedaquiline	To be implemented			E/T
Delamanid				E/T
Pretomanid				E/T
PAS				E/T

Notes: Data from these studies.^19–28

Abbreviations: c.i., continuous infusion; E, efficacy; PAS, para-aminosalicylic acid; T, prevent toxicity; TDM, therapeutic drug monitoring.

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