A 9-Year Experience of Aspergillus Infections from Isfahan, Iran

Figures & data

Table 1 Aspergillus Species Obtained from Different Clinical Samples

Aspergillus spp.	Clinical Symptoms	Male/Female	Total Number	Identification Methods	Accession Numbers
A. flavus/oryzae	RTI (n=31), Onychomycosis (n=16), Sinusitis (n=5), Keratomycosis (n=2)	13/41	54	Phenotypic (n=22) PCR-sequencing (n=32)	N/A MT584269, MT584271-MT584290, MT584292- MT584302
A. fumigatus	RTI (n=10), Onychomycosis (n=7), Sinusitis (n=5), Otomycosis (n=2)	14/10	24	Phenotypic (n=24)	N/A
A. niger	Otomycosis (n=10), Sinusitis (n=6), Onychomycosis (n=2), Keratomycosis (n=1), RTI (n=1), Skin Lesion (n=1)	11/10	21	Phenotypic (n=20) PCR-sequencing (n=1)	N/A MT584291
A. terreus	Onychomycosis (n=7), RTI (n=4), Keratomycosis (n=1)	3/9	12	Phenotypic (n=10) PCR-sequencing (n=2)	N/A MT584270, MT582514
A. nidulans	Onychomycosis (n=4), RTI (n=1), Keratomycosis (n=1)	4/2	6	Phenotypic (n=6)	N/A
A. clavatus	RTI (n=1), Keratomycosis (n=1), Sinusitis (n=1)	1/2	3	Phenotypic (n=3)	N/A
Aspergillus spp.	Sinusitis (n=4), Onychomycosis (n=4), RTI (n=3), Keratomycosis (n=1)	8/4	12	Phenotypic (n=12)	N/A

Abbreviation: RTI, respiratory tract infection.

Figure 1 The frequency of different clinical types of Aspergillus infections from 2010 to 2018.

Table 2 MIC Range, MIC₅₀, MIC₉₀, Geometric Mean (GM) and MIC Values Distribution of the Three Antifungals

Aspergillus Species (No.)	MIC Range (μg/mL)	MIC50 (μg/mL)	MIC90 (μg/mL)	GM	MIC Values (μg/mL)
					0.25	0.5	1	2	4	8	16
A. flavus/oryzae (32)	AMB (0.5–4) ITR (0.5–16) VOR (0.25–8)	1 2 0.5	4 4 2	0.94 1.57 0.82	0 0 5	15 7 12	9 7 6	4 12 6	4 3 2	0 2 1	0 1 0
A. terreus (2)	AMB (4–4) ITR (0.5–1) VOR (0.5–1)	N/A	N/A	4 0.7 0.7	0 0 0	0 1 1	0 1 1	0 0 0	2 0 0	0 0 0	0 0 0
A. niger (1)	AMB (1) ITR (1) VOR (1)	N/A	N/A	N/A	0 0 0	0 0 0	1 1 1	0 0 0	0 0 0	0 0 0	0 0 0

Figure 2 Amphotericin B E-test strip on RPMI medium showed a MIC of 1 µg/mL (susceptible to amphotericin B).

Data Availability

All sequences were deposited in the GenBank database, and accession numbers were obtained for them, and inserted into the manuscript (MT582514, and MT584269 – MT584302).