Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections

Figures & data

Table 1 Patient Characteristics and ICU Admission Data

Characteristics	Death (n=76)	Discharge (n=89)	p-value
Male	43 (56.6%)	45 (50.6%)	0.44
Age, mean ±SD	75±13	65±18	<0.001^a
Re-admission to ICU. n (%)	17 (22.4%)	18 (20.2%)	0.737
Re-admission to ICU within 48 h n (%)	3 (3.9%)	0 (0)	0.059
Location prior to admission			0.122
Emergency	35 (46.1%)	49 (55.1%)
Surgery	7 (9.2%)	11 (12.4%)
Hospital ward	18 (23.7%)	10 (11.2%)
Transfer from different hospital	14 (18.4%)	19 (21.3%)
Comorbidities n (%)
Chronic heart failure	0 (0%)	8 (9%)	0.007
Chronic kidney disease	11 (14.5%)	21 (23.6%)	0.136
Cirrhosis	2 (2.9%)	1 (1.1%)	0.47
Diabetes mellitus	32 (42.1%)	36 (40.4%)	0.829
Cardiovascular disease	17 (22.4%)	28 (31.5%)	0.191
Previous stroke	18 (23.7%)	18 (20.2%)	0.592
Dementia	10 (13.2%)	6 (6.7%)	0.165
Performance status n (%)			0.06
Completely independent	57 (75%)	75 (84.3%)
Partially independent	6 (7.9%)	9 (10.1%)
Fully dependent	13 (17.1%)	5 (5.6%)
Admission clinical data
SAPS3 predicted mortality (median, IQR)	30.51 (20.4–49.3)	15.91 (8.9–25.7)	<0.001
Respiratory rate	20(18–25)	20 (18–22)	0.23
Temperature (ºC)	36 (35.1–36.6)	36 (35.1–36.6)	0.833
Mean arterial pressure (mmHg) (mean ±SD)	92.61 (74.5–107.5)	100.02 (83.5–116.17)	0.025
Glasgow coma score	14 (11–15)	15 (13–15)	0.012
Hematocrit	33±8.1	32.7±8.2	0.828^a
White blood cell (⨰10^3)	12.1 (9–17.1)	12.4 (8.3–17.1)	0.83
Platelets (⨰10^3)	206 (147–308)	272 (194–343)	0.014
Lactate (mmol/L)	1.3 (1–1.9)	1.2 (0.8–1.9)	0.174
Creatinine (mg/dL)	0.9 (0.6–2.3)	0.8 (0.6–2.3)	0.606
Admission C-reactive protein (mg/L)	82.20 (17.30–129)	30.25 (10.14–93.30)	0.021
Peak C-reactive protein (mg/L)	200 (115.5–201)	108 (79.3–198)	<0.001
Outcomes and complications
ICU length of stay (days) (median, IQR)	22 (^Citation14–47)	17 (8–29)	0.025
Mechanical ventilation	34 (44.7%)	25 (28.1%)	0.026
Vasopressors	15 (19.7%)	5 (5.6%)	0.06
Acute kidney injury	12 (15.8%)	6 (6.7%)	0.063
Obtundation	50 (65.8%)	36 (40.4%)	0.001
Septic shock	9 (11.8%)	2 (2.2%)	0.014

Note: ^aChi-squared test.

Figure 1 Adjusted and unadjusted multivariate regression model for ICU mortality. Univariate analysis yielded unadjusted odds of death. Multivariate regression adjusted for differences in baseline characteristics (variables with p<0.1 in univariate comparisons).

Singh JA, Yu S, et al. Utilization due to chronic obstructive pulmonary disease and its predictors: a study using the U.S. National Emergency Department Sample (NEDS). Respir Res. 2016:17(1); 1–9. doi:10.1186/s12931-015-0319-y26739476

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