False-Negative Serum Cryptococcal Antigen Lateral Flow Immunoassay Result for a Patient with Disseminated Cryptococcal Disease

Figures & data

Figure 1 (A) Morphology of C. neoformans in blood culture bottle by Indian ink staining (×400). (B) Colony morphology of C. neoformans on Sabouraud dextrose agar.

Table 1 Reports of False-Negative Cryptococcal Antigen Lateral Flow Assay in Recent Years

Year	Country	Age	Gender	Comorbidities	Clinical Presentation	Specimen	Culture	Bacteria	Treat	Clinical Outcome	Ref. No.
2014	South Africa	59	Not Found	AIDS	Not Found	CSF	Positive	C. neoformans	Not Found	Not Found	[16]
2014	South Africa	59	Not Found	AIDS	Not Found	CSF	Positive	C. neoformans	Not Found	Not Found
2014	South Africa	59	Not Found	AIDS	Not Found	CSF	Positive	C. neoformans	Not Found	Not Found
2018	USA	42	M	AIDS	Weakness, cough, headache	CSF	Positive	C. neoformans	Amphotericin B and Flucytosine	Recover	[15]
2018	USA	49	M	AIDS	Lethargy, febrile, tachycardic	CSF	Not Found	C. neoformans	Amphotericin B and high-dose fluconazole	Not Found	[17]
2016	USA	63	M	NO	Gait dysfunction, headache	CSF	Positive	C. neoformans	Amphotericin B and flucytosine	Not Found	[13]
2018	Australia	Not Found	Not Found	Not Found	Not Found	Serum	Sputa culture was positive	C. gattii	Not Found	Not Found	[14]
2018	Australia	Not Found	Not Found	Not Found	Not Found	Serum	Sputa culture was positive	C. gattii	Not Found	Not Found