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Infection and Drug Resistance Volume 13, 2020 - Issue
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Original Research

Co-Occurrence of the mcr-1.1 and mcr-3.7 Genes in a Multidrug-Resistant Escherichia coli Isolate from China

Chongtao Du1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7485-084X
ORCID Icon,
Yuyang Feng1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of China
,
Guizhen Wang2 College of Food Engineering, Jilin Engineering Normal University, Changchun130052, People’s Republic of China
,
Zhiyuan Zhang1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of China
,
Huimin Hu1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of China
,
Yu Yu1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of China
,
Jiayang Liu1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of China
,
Lihao Qiu1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of China
,
Hongtao Liu1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of China
,
Zhimin Guo3 Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun130021, People’s Republic of China
,
Jing Huang3 Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun130021, People’s Republic of ChinaCorrespondence[email protected]
&
Jiazhang Qiu1 Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun130062, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 3649-3655 | Published online: 19 Oct 2020

Figures & data

Figure 1 Comparison of mcr-carrying plasmids and other closely related plasmids. (A) Comparative analysis of pQDFD216.1 with five closely related mcr-1.1-carrying plasmids including pLD93-1-MCR1 (GenBank accession: CP047664.1), p2HS-C-1 (GenBank accession: CP038181.1), p787-MCR (GenBank accession: MG825367.1), pE13-43-mcr-1 (GenBank accession: LT838201.1) and pWI2-mcr (GenBank accession: LT838201.1). pQDFD216.1 was used as the reference plasmid for BRIG. (B) Comparative analysis of pQDFD216.2 with five closely related mcr-3-carrying plasmids, pMCR3_WCHEC1943 (GenBank accession: MF678351.1), pGDZJ003-1-MCR-3 (GenBank accession: MH043625.1), pMCR3_WCHEC-LL123 (GenBank accession: MF489760.1), pZR12 (GenBank accession: MF455227.1) and pMCR_WCHEC1622 (GenBank accession: KY463452.1). The plasmid pQDFD216.2 was used as the reference plasmid for BRIG.

Figure 1 Comparison of mcr-carrying plasmids and other closely related plasmids. (A) Comparative analysis of pQDFD216.1 with five closely related mcr-1.1-carrying plasmids including pLD93-1-MCR1 (GenBank accession: CP047664.1), p2HS-C-1 (GenBank accession: CP038181.1), p787-MCR (GenBank accession: MG825367.1), pE13-43-mcr-1 (GenBank accession: LT838201.1) and pWI2-mcr (GenBank accession: LT838201.1). pQDFD216.1 was used as the reference plasmid for BRIG. (B) Comparative analysis of pQDFD216.2 with five closely related mcr-3-carrying plasmids, pMCR3_WCHEC1943 (GenBank accession: MF678351.1), pGDZJ003-1-MCR-3 (GenBank accession: MH043625.1), pMCR3_WCHEC-LL123 (GenBank accession: MF489760.1), pZR12 (GenBank accession: MF455227.1) and pMCR_WCHEC1622 (GenBank accession: KY463452.1). The plasmid pQDFD216.2 was used as the reference plasmid for BRIG.

Figure 2 A linear depiction of the genetic configuration of mcr-carrying plasmids compared to other closely related plasmids. (A) Structure comparisons of pQDFD216.1, pmcr1_IncX4 (GenBank accession: KU761327.1) and pCSZ4 (GenBank accession: KX711706.1). (B) Structure comparisons of pQDFD216.2, pGDZJ003-1-MCR-3 (GenBank accession: MH043625.1) and pMCR3_WCHEC-LL123 (GenBank accession: MF489760.1). The map was generated with Easyfig.

Figure 2 A linear depiction of the genetic configuration of mcr-carrying plasmids compared to other closely related plasmids. (A) Structure comparisons of pQDFD216.1, pmcr1_IncX4 (GenBank accession: KU761327.1) and pCSZ4 (GenBank accession: KX711706.1). (B) Structure comparisons of pQDFD216.2, pGDZJ003-1-MCR-3 (GenBank accession: MH043625.1) and pMCR3_WCHEC-LL123 (GenBank accession: MF489760.1). The map was generated with Easyfig.

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