Rifampicin-Resistant Multidrug-Resistant Tuberculosis Cases in Selected Hospitals in Western Oromia, Ethiopia: Cross-Sectional Retrospective Study

Figures & data

Table 1 Distribution of Selected Socio-Demographic Characteristics and Their HIV-Status in Relation to GeneXpert Results Among MDR-TB Suspected Patients in Three Hospitals, West Oromia, Ethiopia, 2016 (n=2300)

Variables	Nekemte Hospital			Gimbi Hospital			Nedjo Hospital
	GeneXpert Results			GeneXpert Results			GeneXpert Results
	MTB^+/RIF^− n=70(%)	MTB^+/RIF^+ n=67(%)	MTB^−/RIF^− n=590(%)	MTB^+/RIF^− n=205(%)	MTB^+/RIF^+ n=37(%)	MTB^−/RIF^− n=926(%)	MTB^+/RIF^− n=89(%)	MTB^+/RIF^+ n=23(%)	MTB^−/RIF^− n=293(%)
Sex
Male	40(57.1)	45(67.2)	331(56.1)	98(47.8)	24(64.9)	432(46.6)	38(42.7)	15(65.2)	136(46.4)
Female	30(42.9)	22(32.8)	259(43.9)	107(52.2)	13(35.1)	494(53.4)	51(57.3)	8(34.8)	157(53.4)
Age
1–15	4(5.7)	2(3.0)	38(6.4)	27(13.2)	4(10.8)	165(17.8)	9(10.1)	2(8.7)	45(15.4)
16–30	24(34.3)	41(61.2)	203(34.4)	95(46.3)	19(51.4)	323(34.9)	46(51.7)	15(65.2)	91(31.1)
31–45	24(34.4)	18(26.9)	172(29.2)	49(23.9)	11(29.7)	236(25.5)	18(20.2)	5(21.7)	87(29.7)
46–60	14(20.0)	5(7.5)	134(22.7)	20(9.8)	3(8.1)	121(13.1)	11(12.4)	1(4.3)	48(16.4)
61–75	2(2.8)	1(1.5)	39(6.6)	8(3.9)	0(0.0)	62(6.7)	3(3.4)	0(0.0)	14(4.8)
≥76	2(2.8)	0(0.0)	4(0.1)	6(2.9)	0(0.0)	19(2.1)	2(2.2)	00(0.0)	8(2.7)
Patient category
New	47(65.3)	10(14.9)	507(85.9)	106(51.7)	5(13.5)	697(75.3)	55(64.0)	5(21.7)	209(71.3)
Relapse	21(29.2)	8(11.9)	68(11.5)	84(40.9)	5(13.5)	198(21.4)	25(28.1)	2(8.7)	68(23.2)
Loss to follow-up	0(0.0)	4(5.97)	5(0.85)	7(3.4)	7(18.9)	12(1.3)	4(4.5)	4(17.4)	4(1.4)
Failure after Rx	2(2.8)	30(44.8)	10(1.7)	4(1.9)	15(40.5)	19(2.1)	2(2.2)	9(39.1)	12(4.1)
MDR-TB contact	0(0.0)	15(22.4)	0(0.0)	4(1.9)	5(13.5)	0(0.0)	3(3.4)	3(13.0)	0(0.0)
HIV-status
Positive	3(4.2)	15(22.4)	57(9.7)	14(6.8)	10(27.0)	95(10.3)	14(15.7)	5(21.7)	24(8.2)
Negative	11(15.3)	51(76.1)	79(13.3)	57(27.8)	26(70.3)	120(13.0)	28(31.5)	16(69.6)	21(7.2)
Unknown	56(77.8)	1(1.5)	454(77)	134(65.4)	1(2.7)	711(76.7)	47(52.8)	2(8.7)	248(84.6)

Abbreviations: MTB⁺/RIF⁻, M. tuberculosis detected; MTB⁺/RIF⁺, M. tuberculosis detected as well as RIF resistance; MTB⁻/RIF⁻, M. tuberculosis no detected as well as RIF resistance.

Table 2 Diagnostic Characteristics of Study Population by Sex and Age in Three Hospitals, 2016

Variables	GeneXpert Results
	MTB^+/RIF^− n=491(%)	COR[95% CI]	P-value	MTB^+/RIF^+ n=127(%)	COR[95% CI]	P-value	MTB^−/RIF^− n=1808(%)	COR[95% CI]	P-value
Sex
Male	260(53.0)	0.9[0.72–1.01]	0.2	84(66.1)	2.0[1.4–2.9]	0.01	899(49.7)	1.2[0.9–1.4]	0.22
Female	231(47.0)	1.0		43(33.9)	1.0		909(50.3)	1.0
Age
1–15	48(9.9)	1.0		8(6.3)	1.0		248(13.7)	1.0
16–30	236(48.5)	0.5[0.35–0.70]	0.01	75(59.1)	0.3(0.14–0.64)	0.001	616(34.1)	2.0[1.4–2.8]	0.981
31–45	125(25.7)	0.8[0.5–1.10]	0.154	34(26.8)	0.5(0.22–1.05)	0.065	495(27.4)	1.3[0.9–1.9]	0.245
46–60	53(10.9)	1.1[0.70–1.7]	0.703	9(7.1)	1.1(0.41–2.82)	0.885	303(16.8)	0.9[0.6–1.4]	0.903
61–75	14(2.9)	1.6[0.80–3.00]	0.152	1(0.8)	3.6(0.44–28.73)	0.234	115(6.4)	0.6[0.3–1.2]	0.651
≥76	10(2.0)	0.6(2.8–1.30)	0.198	0(0.0)	0(0)	-	31(1.7)	1.7[0.8–3.6]	0.453

Abbreviations: MTB⁺/RIF⁻, M. tuberculosis detected; MTB⁺/RIF⁺, M. tuberculosis and resistance to Rif detected; MTB⁻/RIF⁻, M. tuberculosis and resistance to RIF not detected.

Table 3 GeneXpert MTB/RIF Assay in Different Patient Category in Three Hospitals, 2016

Variables	GeneXpert Results
	MTB^+/RIF^− n=491(%)	COR [95% CI]	P-value	MTB^+/RIF^+ n=127(%)	COR [95% CI]	P-value
Patient category
New	228(46.4)	1.0		20(15.7)	1.0
Relapse	145(29.5)	0.4[0.3–0.5]	0.01	15(11.8)	20[17.5,42.5]	0.01
Loss to follow-up	26(5.3)	0.1[0.07–0.2]	0.01	15(11.8)	12[9.8,24.1]	0.01
Failure after Rx	62(12.6)	0.1[0.06–0.16]	0.01	54(42.5)	5[4.7,15.2]	0.01
MDR-TB contact	30(6.1)	0.00	0.997	23(18.1)	3[1.2,7.8]	0.01

Abbreviations: MTB⁺/Rif⁻, M. tuberculosis detected; MTB⁺/Rif⁺, M. tuberculosis detected as well as resistance to RIF.