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Original Research

Primary Drug-Resistance Pattern and Trend in Elderly Tuberculosis Patients in Shandong, China, from 2004 to 2019

, , , , , , , ORCID Icon, , , & show all
Pages 4133-4145 | Published online: 13 Nov 2020

Figures & data

Table 1 Sociodemographic and Clinical Characteristics of Elderly and Non-Elderly Primary TB Patients, Shandong Province, China, 2004–2019

Table 2 Primary Drug Resistance Profiles of Mycobacterium Tuberculosis Between Elderly People and Non-Elderly People, Shandong, China, 2004–2019

Table 3 The Temporal Change Trend of Primary Drug Resistance Rate Among the Elderly TB Cases in Shandong, China, 2004–2019*

Table 4 Changes in Proportions of Different Primary Drug-Resistant Mycobacterium Tuberculosis Subgroups Among the Elderly, Shandong Province, China, 2004–2019

Figure 1 Trends for the quantity and proportions of different subgroups among the total elderly primary DR-TB cases, Shandong, China, 2004–2019*. (A) Trends for MR-TB, MDR-TB, PDR-TB among the elderly with primary TB; (B) Trends for the elderly primary DR-TB cases of different sex (male or female); (C) Trends for primary DR-TB cases with or without cavity; (D) Trends for primary DR-TB cases with or without smoking history; (E) Trends for primary DR-TB cases with or without drinking history; The proportions of each subgroups were calculated as follows: (the quantity of each subgroups/the quantity of the total elderly primary DR-TB subgroups in the same year) × 100%; The χ2 and linear regression results are shown in .

Abbreviations: TB, tuberculosis; DR-TB, drug-resistant tuberculosis; MR-TB, mono-resistant tuberculosis; MDR-TB, multi-resistant tuberculosis; PDR-TB, polydrug resistant tuberculosis; EMB, ethambutol; INH, isoniazid; RFP, rifampin; SM, streptomycin.
Figure 1 Trends for the quantity and proportions of different subgroups among the total elderly primary DR-TB cases, Shandong, China, 2004–2019*. (A) Trends for MR-TB, MDR-TB, PDR-TB among the elderly with primary TB; (B) Trends for the elderly primary DR-TB cases of different sex (male or female); (C) Trends for primary DR-TB cases with or without cavity; (D) Trends for primary DR-TB cases with or without smoking history; (E) Trends for primary DR-TB cases with or without drinking history; The proportions of each subgroups were calculated as follows: (the quantity of each subgroups/the quantity of the total elderly primary DR-TB subgroups in the same year) × 100%; The χ2 and linear regression results are shown in Table 4.

Figure 2 Overall first-line drug resistance for INH, RIF, EMB, and SM among the elderly cases of primary drug-resistant tuberculosis in Shandong, China, 2004–2019. The proportions of INH-, RIF-, EMB-, and SM-resistance were calculated as follows: (the quantity of each subgroups/the quantity of total the elderly primary DR-TB subgroups in the same year) × 100%; The χ2 and linear regression results are shown in .

Abbreviations: EMB, ethambutol; INH, isoniazid; RFP, rifampin; SM, streptomycin.
Figure 2 Overall first-line drug resistance for INH, RIF, EMB, and SM among the elderly cases of primary drug-resistant tuberculosis in Shandong, China, 2004–2019. The proportions of INH-, RIF-, EMB-, and SM-resistance were calculated as follows: (the quantity of each subgroups/the quantity of total the elderly primary DR-TB subgroups in the same year) × 100%; The χ2 and linear regression results are shown in Table 4.