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Original Research

Carbapenemase OXA-423: A Novel OXA-23 Variant in Acinetobacter baumannii

ORCID Icon, , & ORCID Icon
Pages 4069-4075 | Published online: 10 Nov 2020

Figures & data

Table 1 Primers Used in This Study

Figure 1 Sequence alignment of OXA-423 with several OXA-23-like carbapenemases. Conserved motifs are boxed. The Val128Ala substitution in OXA-423 was indicated by a black arrow.

Figure 1 Sequence alignment of OXA-423 with several OXA-23-like carbapenemases. Conserved motifs are boxed. The Val128Ala substitution in OXA-423 was indicated by a black arrow.

Table 2 Antibiotic Susceptibilities of A. baumannii WY-0713 and E. coli Transformants

Figure 2 Active-site tertiary structure comparison of OXA-23-meropenem complex (A) with the model of OXA-423-meropenem complex (B). Distances (Å) are displayed as yellow dashed lines.

Figure 2 Active-site tertiary structure comparison of OXA-23-meropenem complex (A) with the model of OXA-423-meropenem complex (B). Distances (Å) are displayed as yellow dashed lines.