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Infection and Drug Resistance Volume 13, 2020 - Issue
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Original Research

Rapid Identification of KL49 Acinetobacter baumannii Associated with Clinical Mortality

Qiuyang Deng1 Bacteriology & Antibacterial Resistance Surveillance Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Jinyong Zhang2 National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-9622-5834
ORCID Icon,
Min Zhang1 Bacteriology & Antibacterial Resistance Surveillance Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Zhou Liu3 Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
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Yuxin Zhong1 Bacteriology & Antibacterial Resistance Surveillance Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Shiyi Liu1 Bacteriology & Antibacterial Resistance Surveillance Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Ruiqin Cui1 Bacteriology & Antibacterial Resistance Surveillance Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Yun Shi2 National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, People’s Republic of China
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Hao Zeng2 National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, People’s Republic of China
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Xiyao Yang3 Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
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Chuchu Lin4 Department of Nosocomial Infection Control, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Yutian Luo5 Intensive Care Unit, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4943-5078
ORCID Icon,
Huaisheng Chen5 Intensive Care Unit, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Weiyuan Wu6 Department of Clinical Microbiology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Jinsong Wu6 Department of Clinical Microbiology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Tianle Zhang7 Guangdong Medical University, Dongguan, People’s Republic of China
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Yuemei Lu6 Department of Clinical Microbiology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Xueyan Liu5 Intensive Care Unit, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of China
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Quanming Zou2 National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected]
&
Wei Huang1 Bacteriology & Antibacterial Resistance Surveillance Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong518020, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8569-5184
ORCID Icon show all
Pages 4125-4132 | Published online: 12 Nov 2020

Figures & data

Table 1 Distribution of KL49 Capsular Polysaccharide (CPS) Synthesis Genes in Other KL Types

Table 2 KL Types of 61 Clinical Carbapenem Resistant Acinetobacter baumannii Strains in This Study

Figure 1 Virulence potential of Acinetobacter baumannii strains in a mouse infection model. (A–D) The effect of 2.5×108, 1×108, 5×107, 1×107 colony-forming units of each A. baumannii isolate (n=10; *P<0.05, **P<0.001, log-rank test) on survival was assessed in mouse. Strains 5122 and 2092 are two KL49 A. baumannii strains; 7152, 71517 and 20859 are KL3 A. baumannii strains. LAC-4 is a KL49 hypervirulent A. baumannii strain reported in a previous study. LAC-4:Δgtr100 is a gtr100 knockout strain. LAC-4:Δgtr100Ωgtr100 is complemented strain. ATCC17978 is a KL3 A. baumannii strain.

Figure 1 Virulence potential of Acinetobacter baumannii strains in a mouse infection model. (A–D) The effect of 2.5×108, 1×108, 5×107, 1×107 colony-forming units of each A. baumannii isolate (n=10; *P<0.05, **P<0.001, log-rank test) on survival was assessed in mouse. Strains 5122 and 2092 are two KL49 A. baumannii strains; 7152, 71517 and 20859 are KL3 A. baumannii strains. LAC-4 is a KL49 hypervirulent A. baumannii strain reported in a previous study. LAC-4:Δgtr100 is a gtr100 knockout strain. LAC-4:Δgtr100Ωgtr100 is complemented strain. ATCC17978 is a KL3 A. baumannii strain.

Figure 2 Worldwide spread of KL49 Acinetobacter baumannii strains. (A) A phylogenetic tree of the 78 KL49 strains retrieved from NCBI and nine KL49 strains in this study. LAC-4 was used as reference. The colors of the isolate tips represent the country of isolation. STs are shown in the outer ring. (B) An unrooted version of the tree shown in (A).

Figure 2 Worldwide spread of KL49 Acinetobacter baumannii strains. (A) A phylogenetic tree of the 78 KL49 strains retrieved from NCBI and nine KL49 strains in this study. LAC-4 was used as reference. The colors of the isolate tips represent the country of isolation. STs are shown in the outer ring. (B) An unrooted version of the tree shown in (A).

Table 3 Univariable Logistic Regression Analysis of the Factors Associated with Mortality

Table 4 Multivariable Logistic Regression Analysis of the Factors Associated with Mortality

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