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Original Research

Rapid Identification of KL49 Acinetobacter baumannii Associated with Clinical Mortality

, ORCID Icon, , , , , , , , , , ORCID Icon, , , , , , , & ORCID Icon show all
Pages 4125-4132 | Published online: 12 Nov 2020

Figures & data

Table 1 Distribution of KL49 Capsular Polysaccharide (CPS) Synthesis Genes in Other KL Types

Table 2 KL Types of 61 Clinical Carbapenem Resistant Acinetobacter baumannii Strains in This Study

Figure 1 Virulence potential of Acinetobacter baumannii strains in a mouse infection model. (AD) The effect of 2.5×108, 1×108, 5×107, 1×107 colony-forming units of each A. baumannii isolate (n=10; *P<0.05, **P<0.001, log-rank test) on survival was assessed in mouse. Strains 5122 and 2092 are two KL49 A. baumannii strains; 7152, 71517 and 20859 are KL3 A. baumannii strains. LAC-4 is a KL49 hypervirulent A. baumannii strain reported in a previous study. LAC-4:Δgtr100 is a gtr100 knockout strain. LAC-4:Δgtr100Ωgtr100 is complemented strain. ATCC17978 is a KL3 A. baumannii strain.

Figure 1 Virulence potential of Acinetobacter baumannii strains in a mouse infection model. (A–D) The effect of 2.5×108, 1×108, 5×107, 1×107 colony-forming units of each A. baumannii isolate (n=10; *P<0.05, **P<0.001, log-rank test) on survival was assessed in mouse. Strains 5122 and 2092 are two KL49 A. baumannii strains; 7152, 71517 and 20859 are KL3 A. baumannii strains. LAC-4 is a KL49 hypervirulent A. baumannii strain reported in a previous study. LAC-4:Δgtr100 is a gtr100 knockout strain. LAC-4:Δgtr100Ωgtr100 is complemented strain. ATCC17978 is a KL3 A. baumannii strain.

Figure 2 Worldwide spread of KL49 Acinetobacter baumannii strains. (A) A phylogenetic tree of the 78 KL49 strains retrieved from NCBI and nine KL49 strains in this study. LAC-4 was used as reference. The colors of the isolate tips represent the country of isolation. STs are shown in the outer ring. (B) An unrooted version of the tree shown in (A).

Figure 2 Worldwide spread of KL49 Acinetobacter baumannii strains. (A) A phylogenetic tree of the 78 KL49 strains retrieved from NCBI and nine KL49 strains in this study. LAC-4 was used as reference. The colors of the isolate tips represent the country of isolation. STs are shown in the outer ring. (B) An unrooted version of the tree shown in (A).

Table 3 Univariable Logistic Regression Analysis of the Factors Associated with Mortality

Table 4 Multivariable Logistic Regression Analysis of the Factors Associated with Mortality