Clinical Analysis of Bloodstream Infections During Agranulocytosis After Allogeneic Hematopoietic Stem Cell Transplantation

Figures & data

Table 1 Resistance Rate of Major Gram-Negative Bacteria to Common Antibacterial Drugs

Antibacterial Drugs	Escherichia coli		Klebsiella pneumoniae		Pseudomonas aeruginosa
	Number	Rate(%)	Number	Rate(%)	Number	Rate (%)
Piperacillin/Tazobactam	5	33.3	5	50.0	4	57.1
Cefazolin	14	93.3	6	60.0	5	83.3
Cefotetan	5	35.7	3	33.3	6	100.0
Ceftazidime	8	57.1	4	44.4	4	57.1
Ceftriaxone	12	80.0	5	50.0	5	83.3
Cefepime	7	46.7	4	40.0	4	57.1
Imipenem	1	6.7	3	30.0	2	28.6
Amikacin	2	13.3	1	10.0	1	14.3
Gentamicin	10	66.7	2	20.0	5	71.4
Ciprofloxacin	12	80	4	40.0	1	14.3
Levofloxacin	11	73.3	4	40.0	1	14.3
Compound trimethoprim	13	86.7	6	60.0	5	83.3
Tigecycline	0	0	0	0	–	–
Cefoperazone/Sulbactam	3	20.0	–	–	–	–
Meropenem	–	–	–	–	2	28.6

Figure 1 Distribution of 60 isolated pathogenic bacteria pathogen.

Table 2 Univariate Analysis of Risk Factors for BSI

Factors	Total Numbers of Cases	BSI	χ^2	P
Recipient’s Sex
Male	242	31 (12.8%)	0.045	0.832
Female	155	21 (13.5%)
Recipient’s Age
≥14	279	40 (14.3%)	1.265	0.261
˂14	118	12 (10.2%)
Primary Diseases
AML	115	17 (14.8%)	6.440	0.092
ALL	102	7 (6.9%)
AA	110	20 (18.2%)
Others	70	8 (11.4%)
Type of transplant
Matched sibling donor	177	17 (9.60%)	7.272	0.026
Partially matched related	165	22 (13.3%)
Matched unrelated	55	13 (23.6%)
Source of stem cells
PB	333	44 (13.2%)	9.413	0.009
CB	9	4 (44.4%)
PB+BM	55	4 (7.3%)
ATG in regimen
Yes	272	45 (16.5%)	9.012	0.003
No	125	7 (5.6%)
Days of neutropenia
≥21	70	26 (37.1%)	43.165	0.000
˂21	327	26 (8.0%)
Diarrhea
Yes	174	27 (15.5%)	1.592	0.207
No	223	25 (11.2%)
Oral ulcer
Yes	244	30 (12.3%)	0.359	0.549
No	153	22 (14.4%)

Table 3 Multivariate Analysis of Risk Factors for BSI

Risk Factors	Wald	P-value	Exp (B)	95%CI
Type of transplant	1.265	0.531	-	-
Partially matched related	0.436	0.509	0.756	0.330–1.732
Matched unrelated	0.172	0.678	1.250	0.436–3.578
Source of stem cells	8.209	0.016	-	-
PB	4.011	0.045	3.197	1.025–9.969
CB	7.875	0.005	24.784	2.633–233.279
ATG in regimen	4.832	0.028	3.401	1.142–10.132
Days of neutropenia ≥21	28.265	0.000	6.407	3.231–12.707