Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naïve HIV-1-Infected Adults in Guangdong Province, China, in 2018

Figures & data

Table 1 Demographic and Viral Characteristics of 827 Study Population

Characteristics	Individuals (%)	Cases Related to INI Mutations (%)
		Cases	%
Patient, no.	827	12	1.45
Gender, no. (%)
Male	713(86.22)	10	1.40
Female	114(13.78)	2	1.75
Route of infection, no. (%)
Heterosexual	328(39.66)	6	1.83
MSM	409(49.46)	4	0.98
IDU	35(4.23)	2	5.71
Blood	5(0.60)	0	0.00
SexIDU	9(1.09)	0	0.00
Others	43(5.20)	0	0.00
Geographical region, no. (%)
Pear River Delta	689(83.31)	11	1.60
Eastern	39(4.72)	0	0.00
Western	48(5.80)	1	2.08
Northern	51(6.17)	0	0.00
HIV-1 subtype based on PR/RT sequences, no. (%)
CRF01_AE	314(37.97)	1	0.32
CRF07_BC	268(32.41)	6	2.24
CRF55_01B	102(12.33)	0	0.00
B	28(3.39)	2	7.14
CRF59_01B	22(2.66)	1	4.55
CRF08_BC	18(2.18)	1	5.56
Other (C, G, CRF67_01B, CRF68_01B)	8(0.97)	0	0.00
URF	67(8.10)	1	1.49
HIV-1 viral loads (Log 10, IU/mL), no. (%)
<4	197(23.82)	3	1.52
4~5	141(17.05)	2	1.42
>5	489(59.13)	5	1.02
CD4^+ T cell count (cells/mm^3), no. (%)
<200	350(42.32)	3	0.86
200–350	296(35.79)	5	1.69
351–500	115(13.91)	2	1.74
>500	66(7.98)	0	0.00

Note: Others including unknown and not clear.

Abbreviations: INI, integrase inhibitor; MSM, men who have sex with men; IDU, injection drug user; URF, unique recombination form.

Table 2 Characteristics of Patients Harboring HIV-1 Integrase Inhibitor Mutations

Sample ID	Geographical Region	Gender	Age	Transmission Route	Genotype Based on PR/RT Sequences	INI Resistance Mutations
						Major	Accessory
01032	Pear River Delta	Male	35	MSM	B	–	E157Q
02063	Pear River Delta	Male	65	HTS	CRF_07BC	–	G163R
02072	Pear River Delta	Male	44	HTS	CRF_07BC	–	E157Q
03012	Pear River Delta	Male	40	IDU	CRF_08BC	–	E157Q
03028	Pear River Delta	Male	45	HTS	CRF_5901B	–	E157Q
03059	Pear River Delta	Male	44	HTS	B	–	E157Q
08060	Pear River Delta	Male	28	MSM	CRF_01AE	–	E157Q
08062	Pear River Delta	Male	29	MSM	URF	–	T97A
00067	Western	Female	58	HTS	CRF_07BC	–	E157Q
00169	Pear River Delta	Male	32	MSM	CRF_07BC	–	G163R
00292	Pear River Delta	Female	66	HTS	CRF_07BC	–	A128T
00346	Pear River Delta	Male	22	IDU	CRF_07BC	–	A128T

Abbreviations: INI, integrase inhibitor; MSM, man who have sex with man; IDU, injection drug user; URF, unique recombination form.