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Original Research

PspA Diversity, Serotype Distribution and Antimicrobial Resistance of Invasive Pneumococcal Isolates from Paediatric Patients in Shenzhen, China

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Pages 49-58 | Published online: 11 Jan 2021

Figures & data

Table 1 Demographical and Clinical Characteristics of 81 Patients

Figure 1 PspA families and clades of Shenzhen`s isolates. PspA clades 1–6 were highlighted by red, yellow, green, blue, pink and purple respectively. The black solid circles indicate the 24 strains reported previously, which were identified using their names.

Figure 1 PspA families and clades of Shenzhen`s isolates. PspA clades 1–6 were highlighted by red, yellow, green, blue, pink and purple respectively. The black solid circles indicate the 24 strains reported previously, which were identified using their names.

Figure 2 Serotype distribution before and after PCV13 introduction. B represents before introduction of PCV13, and A represents after introduction of PCV13. Each serotype is colored specifically. The height of the column indicates the composition ratio of the serotype in either period. The proportion of PspA family 1, 2 and 3 are expressed by different filling patterns.

Figure 2 Serotype distribution before and after PCV13 introduction. B represents before introduction of PCV13, and A represents after introduction of PCV13. Each serotype is colored specifically. The height of the column indicates the composition ratio of the serotype in either period. The proportion of PspA family 1, 2 and 3 are expressed by different filling patterns.

Table 2 Susceptibility and MIC of Antibiotics for IPD Isolates in Shenzhen

Figure 3 The multiple drug resistance rate of prevalent serotypes in Shenzhen. Vaccine serotypes refers to the serotypes covered by PCVs, which are colored by blue. The non-vaccine serotypes were not covered by PCVs and are colored by red. The proportion of MDR and non-MDR are distinguished by different filling patterns.

Figure 3 The multiple drug resistance rate of prevalent serotypes in Shenzhen. Vaccine serotypes refers to the serotypes covered by PCVs, which are colored by blue. The non-vaccine serotypes were not covered by PCVs and are colored by red. The proportion of MDR and non-MDR are distinguished by different filling patterns.

Figure 4 The goeBURST analysis of serotype 3. PHYLOViZ was used to identify the relationship of clonal complexes (CCs) of serotype 3 globally. Each node represents a ST. STs found in Shenzhen are colored with dark blue (ST 505), sky blue (ST 4655) and orange (ST 12902), respectively. STs colored with yellow are from foreign countries.

Figure 4 The goeBURST analysis of serotype 3. PHYLOViZ was used to identify the relationship of clonal complexes (CCs) of serotype 3 globally. Each node represents a ST. STs found in Shenzhen are colored with dark blue (ST 505), sky blue (ST 4655) and orange (ST 12902), respectively. STs colored with yellow are from foreign countries.