Clinical Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Among Pediatric Patients in Jiangsu Province, China

Figures & data

Table 1 Clinical Characteristics of the CRKP Strains

Characteristics	n=94
Age in months (median)	4
Male gender	59 (62.8%)
Specimen
Sputum	68 (72.3%)
Urine	9 (9.6%)
Blood	8 (8.5%)
Others	9 (9.6%)
Wards
PICU	25 (26.6%)
Pneumology department	13 (13.9%)
CCU	13 (13.9%)
Neonatal medicine	12 (12.8%)
Others	31 (33.0%)
Diseases
Pneumonia	59 (62.8%)
Sepsis	17 (18.1%)
Cerebral disease	3 (3.2%)
Urinary tract infection	1 (1.1%)
Underlying conditions
Chronic Heart Disease	8 (8.5%)
Neonatal Respiratory Distress Syndrome	3 (3.2%)
Gastroenteritis	2 (2.1%)
Immunodeficiency	2 (2.1%)
Outcome
Cure	90 (95.7%)
Death	4 (4.3%)

Abbreviations: PICU, pediatric intensive care unit; CCU, cardiac care unit.

Table 2 Antimicrobial Susceptibility Patterns of CRKP Strains, % (n)

Antibiotics	Susceptible	Intermediate	Resistant
Imipenem	1.1 (1)	0.0 (0)	98.9 (93)
Meropenem	0.0 (0)	0.0 (0)	100.0 (94)
Piperacillin-tazobactam	0.0 (0)	0.0 (0)	100.0 (94)
Cefazolin	0.0 (0)	0.0 (0)	100.0 (94)
Cefuroxime	0.0 (0)	0.0 (0)	100.0 (94)
Ceftazidime	0.0 (0)	0.0 (0)	100.0 (94)
Cefepime	0.0 (0)	0.0 (0)	100.0 (94)
Aztreonam	4.3 (4)	0.0 (0)	95.7 (90)
Ciprofloxacin	18.1 (17)	2.1% (2)	79.8 (75)
Amikacin	43.6 (41)	0.0 (0)	56.4 (53)
Sulfamethoxazole	85.1 (80)	0.0 (0)	14.9 (14)
Tigecycline	100.0 (94)	0.0 (0)	0.0 (0)
Colistin	100.0 (94)	0.0 (0)	0.0 (0)

Figure 1 Minimum spanning trees of 94 CRKP isolates. Each node represents a single ST. The size of the nodes was proportional to the number of strains within the represent ST. The color distribution represents distribution of carbapenemase genes among different STs.

Figure 2 Dendrogram of PFGE profiles of 71 CRKP ST11 isolates. The UPGMA algorithm was performed to construct a dendrogram based on the dice similarity coefficient. Strains were classified as the same clone cluster when their dice similarity index was ≥80%.

Abbreviations: SICU, surgical intensive care unit; PICU, pediatric intensive care unit; CCU, cardiac care unit.

Figure 3 Dendrogram of PFGE profiles of 23 CRKP non-ST11 strains. The UPGMA algorithm was performed to construct dendrogram based on the dice similarity coefficient. Strains were classified as the same clone cluster when their dice similarity index was ≥80%.

Abbreviations: PICU, pediatric intensive care unit; CCU, cardiac care unit; SICU, surgical intensive care unit; NICU, cardiac care unit.