Resistance Trends of Klebsiella pneumoniae Causing Urinary Tract Infections in Chongqing, 2011–2019

Figures & data

Figure 1 Distribution of strains isolated from urine for the 9-year study.

Abbreviations:E. coli, Escherichia coli; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; E. faecalis, Enterococcus faecalis; E. faecium, Enterococcus faecium.

Table 1 Resistance Rates (%) of Urine K. pneumoniae Isolates to Antimicrobial Agents

Antibiotics	2012		2013		2014		2015		2016		2017		2018		2019
	n = 137		n = 205		n = 189		n = 203		n = 177		n = 191		n = 182		n = 167
	n	R%	n	R%	n	R%	n	R%	n	R%	n	R%	n	R%	n	R%
SAM	137	62.0	205	56.1	183	59.0	188	49.5	172	55.8	188	60.6	182	50.5	/	/
TZP	137	4.4	205	1.5	183	2.2	188	5.9	172	11.6	188	23.4	182	13.7	167	25.7
CAZ	137	31.4	205	28.8	183	26.8	188	21.8	172	27.3	188	35.6	182	28.0	167	29.3
CRO	137	56.9	205	56.6	183	53.0	188	43.1	172	43.6	190	53.7	182	45.6	167	46.7
FEP	137	18.2	205	17.6	183	15.3	188	11.2	172	19.2	188	30.9	182	22.0	167	30.5
CTT	137	2.9	205	0.5	183	2.7	188	4.3	172	11.0	188	19.1	182	15.4	/	/
FOX	/	/	/	/	/	/	155	13.5	158	24.7	180	28.9	181	28.7	136	28.7
ATM	137	35.8	205	36.6	183	36.6	188	32.4	172	32.6	188	39.4	180	32.2	145	34.5*
ETP	133	6.0	200	2.0	182	3.3	182	4.4	171	9.9	190	22.6	182	17.0	167	16.8
IPM	137	1.5	205	0	183	0.5	188	4.3	172	8.7	190	20.0	182	13.7	167	11.4
MEM	/	/	/	/	/	/	163	4.3*	159	8.2*	184	18.5*	181	13.8*	153	11.1*
AMK	137	7.3	205	6.8	175	6.3	175	6.9	164	10.4	181	21.5	182	15.4	167	10.8
GEN	137	42.3	205	51.7	183	41.5	188	33.5	175	38.3	190	45.8	182	34.1	51	23.5
TOB	137	14.6	204	21.1	183	22.4	188	14.9	172	16.9	188	33.0	182	19.8	/	/
CIP	137	55.5	205	51.2	183	59.0	188	48.9	172	54.1	188	58.5	182	52.2	/	/
LVX	137	38.0	205	35.6	183	41.0	188	37.8	172	39.0	188	38.3	182	40.1	167	36.5
SXT	50	54.0	205	53.2	183	60.1	187	46.0	172	54.7	188	50.5	181	41.4	167	43.1

Notes: *The data are results using Kirby-Bauer method; /, the data are not detected.

Abbreviations: SAM, ampicillin/sulbactam; TZP, piperacillin/tazobactam; CAZ, ceftazidime; CRO, ceftriaxone; FEP, cefepime; CTT, cefotetan; FOX, cefoxitin; ATM, aztreonam; ETP, ertapenem; IPM, imipenem; MEM, meropenem; AMK, amikacin; GEN, gentamicin; TOB, tobramycin; CIP, ciprofloxacin; LVX, levofloxacin; SXT, sulfamethoxazole/trimethoprim.

Figure 2 Rates of ESBL-producing and Carbapenem resistant-K. pneumoniae from 2011 to 2019.

Abbreviations: CR-KPN, carbapenem resistant-K. pneumoniae; ESBL-KPN, ESBL-producing K. pneumoniae.

Table 2 Resistance Rates of Urine K. pneumoniae Isolates with Diverse Characteristics to Antimicrobial Agents

Antibiotics	ESBL(+)-KPN		ESBL(-)-KPN		CR-KPN		CSE-KPN
	R (%)	S (%)	R (%)	S (%)	R (%)	S (%)	R (%)	S (%)
SAM	85.3 (480/563)	2.8 (16/563)	34.5 (268/777)	60.6 (471/777)	100.0 (122/122)	0 (0/122)	50.8 (599/1180)	40.6 (480/1180)
TZP	6.6 (41/617)	83.6 (516/617)	13.6 (120/884)	82.4 (728/884)	79.2 (118/149)	9.4 (14/149)	3.2 (42/1314)	91.2 (1198/1314)
CAZ	43.6 (269/617)	50.2 (310/617)	18.3 (162/885)	80.5 (712/885)	96.6 (144/149)	3.4 (5/149)	20.5 (269/1314)	75.9 (997/1314)
CRO	95.8 (591/617)	3.4 (21/617)	17.8 (158/886)	81.6 (723/886)	98.7 (147/149)	1.3 (2/149)	44.3 (583/1316)	55.1 (725/1316)
FEP	25.6 (158/617)	70.5 (435/617)	12.2 (108/885)	86.9 (769/885)	85.9 (128/149)	8.7 (13/149)	10.3 (135/1314)	88.1 (1158/1314)
CTT	1.8 (10/563)	96.4 (543/563)	11.7 (91/777)	86.5 (672/777)	76.2 (93/122)	14.8 (18/122)	0.5 (6/1180)	98.6 (1163/1180)
FOX	22.9 (64/279)	71.3 (199/279)	25.8 (138/534)	71.2 (380/534)	99.1 (111/112)	0.9 (1/112)	12.8 (85/664)	82.8 (550/664)
ATM	62.6 (382/610)	35.7 (218/610)	15.0 (131/872)	84.5 (737/872)	92.3 (132/143)	7.0 (10/143)	28.0 (364/1300)	71.0 (923/1300)
ETP	4.2 (26/615)	94.6 (582/615)	13.5 (119/880)	85.8 (755/880)	100.0 (149/149)	0 (0/149)	0 (0/1316)	100.0 (1316/1316)
IPM	0.6 (4/617)	98.9 (610/617)	11.5 (102/886)	88.0 (780/886)	71.8 (107/149)	22.8 (34/149)	0 (0/1316)	100.0 (1316/1316)
MEM	1.4 (4/287)	97.2 (279/287)	16.2 (90/557)	83.5 (465/557)	80.0 (92/115)	15.7 (18/115)	0 (0/686)	100 (686/686)
AMK	8.2 (49/597)	91.6 (547/597)	12.2 (106/868)	87.8 (762/868)	66.9 (97/145)	33.1 (48/145)	4.3 (55/1284)	95.6 (1228/1284)
GEN	64.8 (378/583)	34.1 (199/583)	23.0 (190/826)	76.3 (630/826)	76.3 (100/131)	22.9 (30/131)	36.5 (451/1235)	62.9 (777/1235)
TOB	26.3 (148/563)	29.3 (165/563)	16.1 (125/777)	71.9 (559/777)	76.2 (93/122)	10.7 (13/122)	14.6 (172/1180)	58.8 (694/1180)
CIP	51.1 (313/613)	40.6 (249/613)	27.5 (241/876)	70.2 (615/876)	91.7 (133/145)	6.9 (10/145)	30.7 (400/1305)	64.2 (838/1305)
LVX	38.9 (240/617)	54.0 (333/617)	24.1 (213/884)	73.0 (645/884)	87.2 (130/149)	11.4 (17/149)	23.2 (305/1314)	71.6 (941/1314)
SXT	80.4 (456/567)	19.6 (111/567)	32.8 (277/846)	67.2 (569/846)	60.6 (87/143)	39.4 (56/143)	51.0 (630/1236)	49.0 (606/1236)

Abbreviations: ESBL(+)-KPN, ESBL-producing K. pneumoniae; ESBL(-)-KPN, non ESBL-producing K. pneumoniae; CR-KPN, carbapenem-resistant K. pneumoniae; CS-KPN, carbapenem-sensitive K. pneumoniae; SAM, ampicillin/sulbactam; TZP, piperacillin/tazobactam; CAZ, ceftazidime; CRO, ceftriaxone; FEP, cefepime; CTT, cefotetan; FOX, cefoxitin; ATM, aztreonam; ETP, ertapenem; IPM, imipenem; MEM, meropenem; AMK, amikacin; GEN, gentamicin; TOB, tobramycin; CIP, ciprofloxacin; LVX, levofloxacin; SXT, sulfamethoxazole/trimethoprim.