Magnitude of Mycobacterium tuberculosis Infection and Its Resistance to Rifampicin Using Xpert-MTB/RIF Assay Among Presumptive Tuberculosis Patients at Motta General Hospital, Northwest Ethiopia

Figures & data

Table 1 Socio-Demographic Characteristics of Study Participants Tested by GeneXpert at Shegaw Motta General Hospital, Northwest Ethiopia, 2020

Variables	Categories	GeneXpert for M. tuberculosis (MTB)
		Positive N (%)	Negative N (%)	Total N(%)	P-value
Sex	Male	176 (4.3)	1972 (48.0)	2148 (52.3)	<0.584
	Female	170 (4.1)	1791 (43.6)	1961 (47.7)
Age (in years)	<15	32 (0.8)	234 (5.9)	275 (6.7)	<0.001
	15–24	88 (2.1)	427 (10.4)	515 (12.5)
	25–44	163 (4.0)	1390 (33.8)	1553 (37.8)
	45–64	57 (1.4)	1290 (31.4)	1347 (32.8)
	>64	6 (0.1)	413 (11.0)	419 (10.2)
Residence	Urban	95 (2.3)	1528 (37.2)	1623 (39.5)	<0.001
	Rural	251 (6.1)	2235 (54.4)	2486 (60.5)
HIV status	Unknown	222 (5.4)	2731 (66.5)	2953 (71.9)	0.002
	Positive	48 (1.2)	353 (8.6)	401 (9.8)
	Negative	76 (1.8)	679 (16.5)	755 (18.4)
Patient registration group	New	314 (7.6)	3713 (90.4)	4027 (98.0)	<0.001
	Relapse	28 (0.6)	48 (1.2)	74 (1.8)
	Defaulter	1 (0.0)	1 (0.0)	2 (0.0)
	Rx failure	5 (0.1)	1 (0.0)	6 (0.1)
Year of GeneXpert done	2015	51 (1.2)	264 (6.4)	315 (7.7)	<0.001
	2016	76 (1.8)	739 (18.0)	815 (19.8)
	2017	75 (1.8)	873 (21.2)	948 (23.1)
	2018	81 (2.0)	1018 (24.8)	1099 (26.7)
	2019	63 (1.5)	869 (21.1)	932 (22.7)
Total		346 (8.4)	3763 (91.6)	4109 (100.0)

Abbreviations: MTB, Mycobacterium tuberculosis; N, frequency; %, percent; Rx, treatment.

Figure 1 Mycobacterium tuberculosis detection by GeneXpert at Motta General Hospital, 2020.

Table 2 Rifampicin Resistance Profile Detected Among MTB Positive at Shegaw Motta General Hospital, Northwest Ethiopia, 2020

Variables	Categories	Resistance Profile		Total	P-value
		Resistance	Sensitive
Sex	Male	10(2.9%)	166(48.0%	176(50.9%)	0.199
	Female	5(1.4%)	165(47.7%)	170(49.1%)
Residence	Urban	7(2.0%	88(25.4%)	95(27.5%)	0.094
	Rural	8(2.3%)	243(70.2%)	251(72.5%
HIV status	Unknown	9(2.6%)	213(61.6%)	222(64.2%)	0.932
	Positive	2(0.6%)	46(13.3%)	48(13.9%)
	Negative	4(1.2%)	72(20.8)	76(22.0%)
Patients registration group	New	13(3.8%)	301(87.0%)	314(90.8%)	0.001
	Relapse	0(0)	26(7.5%)	26(7.5%)
	Defaulter	0(0)	1(0.3%)	1(0.3%)
	Rx failure	2(0.6%)	3(0.9%)	5(1.4%)
Types of TB	PTB	13(3.8%)	310(89.6%)	323(93.4)	0.288
	EPT	2(0.6%)	21(6.1%)	23(6.6%)

Table 3 Multivariate Analysis of Factors Associated with MTB Positive in Motta General Hospital, Ethiopia, 2020

Variables	MTB	MTB	COR (95% CI)	P -value
	Positive	Negative
	N=346	N=3793
Gender
Male	176	1972	1.04(0.84–1.30)	0.7
Female	170	1791	1
Residence
Urban	95	1528	1.79(1.39–2.28)	<0.001
Rural	251	2235	1
HIV status
Positive	48	353	1.40(1.06–1.84)	0.017
Negative	76	679	0.89(0.60–1.30)	0.52
Unknown	222	2731	1

Table 4 Multivariate Analysis of Factors Associated with MTB/RR Positive Among MTB Positive Patients in Motta General Hospital, Ethiopia, 2020

Variables	MTB (+)/	MTB +/	COR(95% CI)	P value
	RR Resistance	RR Sensitive
	N=15	N=331
Gender
Male	10	166	0.53(0.18–1.58)	0.253
Female	5	165	1
Residence
Urban	7	88	0.44(0.16–1.27)	0.13
Rural	8	243	1
HIV status
Positive	2	46	1.12(0.33–3.80)	0.85
Negative	4	72	1.10(0.19–6.35)	0.915
Unknown	9	213	1