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Original Research

Anti-Septic Potential of 7-α-Obacunyl Acetate Isolated from the Toona sinensis on Cecal Ligation/Puncture Mice via Suppression of JAK-STAT/NF-κB Signal Pathway

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Pages 1813-1821 | Published online: 14 May 2021

Figures & data

Figure 1 Chemical structure of 7-OBA isolated from the Toona sinensis.

Figure 1 Chemical structure of 7-OBA isolated from the Toona sinensis.

Figure 2 Effects of 7-OBA on percent survival of CLP mice. As compared with the sham group. ##p<0.01 indicates an extremely significant difference; As compared with the control group, *p< 0.05 indicates a significant difference, **p<0.01 indicates an extremely significant difference.

Figure 2 Effects of 7-OBA on percent survival of CLP mice. As compared with the sham group. ##p<0.01 indicates an extremely significant difference; As compared with the control group, *p< 0.05 indicates a significant difference, **p<0.01 indicates an extremely significant difference.

Figure 3 Effect of 7-OBA on body temperature of CLP mice. ##p<0.01 indicates an extremely significant difference; As compared with the control group, *p< 0.05 indicates a significant difference, **p<0.01 indicates an extremely significant difference.

Figure 3 Effect of 7-OBA on body temperature of CLP mice. ##p<0.01 indicates an extremely significant difference; As compared with the control group, *p< 0.05 indicates a significant difference, **p<0.01 indicates an extremely significant difference.

Figure 4 Effects of 7-OBA on TNF-α, IL-1β, IL-6, and IL-10 of mice after CLP surgery. ##p<0.01 indicates an extremely significant difference; As compared with the control group, *p< 0.05 indicates a significant difference, **p<0.01 indicates an extremely significant difference.

Figure 4 Effects of 7-OBA on TNF-α, IL-1β, IL-6, and IL-10 of mice after CLP surgery. ##p<0.01 indicates an extremely significant difference; As compared with the control group, *p< 0.05 indicates a significant difference, **p<0.01 indicates an extremely significant difference.

Figure 5 Effects of 7-OBA on the function indexes of kidney, liver, and heart in mice after CLP surgery. ##p<0.01 indicates an extremely significant difference; as compared with the control group, **p<0.01 indicates an extremely significant difference.

Figure 5 Effects of 7-OBA on the function indexes of kidney, liver, and heart in mice after CLP surgery. ##p<0.01 indicates an extremely significant difference; as compared with the control group, **p<0.01 indicates an extremely significant difference.

Figure 6 Effects of 7-OBA on NF-κB signal pathway in LPS-stimulated RAW264.7 cells. As compared with the control group, **p<0.01 indicates an extremely significant difference.

Figure 6 Effects of 7-OBA on NF-κB signal pathway in LPS-stimulated RAW264.7 cells. As compared with the control group, **p<0.01 indicates an extremely significant difference.

Figure 7 Effects of 7-OBA on JAK2-STAT3 signal pathway in LPS-stimulated RAW264.7 cells. As compared with the control group, **p<0.01 indicates an extremely significant difference.

Figure 7 Effects of 7-OBA on JAK2-STAT3 signal pathway in LPS-stimulated RAW264.7 cells. As compared with the control group, **p<0.01 indicates an extremely significant difference.