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Infection and Drug Resistance Volume 14, 2021 - Issue
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Case Report

Acquired Resistance to Isoniazid During Isoniazid Monotherapy in a Subject with Latent Infection Following Household Rifampicin-Resistant Tuberculosis Contact: A Case Report

Tsung-Lun Li1 Department of Internal Medicine, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan
,
Tai-Hua Chan2 Taiwan Centers for Disease Control, Taipei, Taiwan
,
Cheng-Hui Wang3 Pulmonary Research Center, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan;4 Department of Laboratory Medicine, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan;5 School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
,
Ruwen Jou2 Taiwan Centers for Disease Control, Taipei, Taiwan;6 Institute of Microbiology and Immunology, National Yang-Ming Chiao Tung University, Taipei, Taiwan
,
Ming-Chih Yu1 Department of Internal Medicine, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan;3 Pulmonary Research Center, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan;7 Schools of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
,
Denise Utami Putri3 Pulmonary Research Center, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan
,
Chih-Hsin Lee1 Department of Internal Medicine, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan;3 Pulmonary Research Center, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan;8 Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanCorrespondence[email protected] [email protected]
&
Yi-Hsien Lin3 Pulmonary Research Center, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan
 show all
Pages 1505-1509 | Published online: 20 Apr 2021

Figures & data

Figure 1 The timeline from the episodes of care of both patients.

Abbreviations: TB, Tuberculosis; AFB, acid-fast bacillus; CDC, Centers for Disease Control; RR, rifampicin-resistant; INH, isoniazid; MDR, multi-drug resistant; AE, adverse events.
Figure 1 The timeline from the episodes of care of both patients.

Figure 2 Chest radiography images (A) before and (B) after nine months of isoniazid treatment for the patient who progressed to active disease following the latent tuberculosis infection treatment.

Figure 2 Chest radiography images (A) before and (B) after nine months of isoniazid treatment for the patient who progressed to active disease following the latent tuberculosis infection treatment.

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