A Case of Sepsis Due to Carbapenem-Resistant Klebsiella pneumoniae in an Extremely Low-Birth Weight Infant Treated with Trimethoprim–Sulfamethoxazole

Figures & data

Table 1 The Usage of Antimicrobials and Efficacy in Cases of Neonatal Sepsis

Author (Year of Publication)	Pathogen	Usage of Antimicrobials	Efficacy	Side Effects
Shobowale et al (2017)^Citation14	CONS and K. Pneumoniae	Meropenem, ciprofloxacin, and amikacin	Most effective antimicrobials in vitro	/
Esposito et al (2019)^Citation8	CRKP	CAZ-AVI/ phosphomycin/ meropenem combination	Recurrent CRKP sepsis	Moderate thrombocytopenia
Jasani et al (2016)^Citation9	Acinetobacter baumannii, K. Pneumoniae and Pseudomonas aeruginosa	Intravenous colistin	Only one of seven with K. Pneumoniae infection survived	None neurotoxicity or nephrotoxicity
Su et al (2019)^Citation12	CRKP	TMP-SMZ /colistin combination	Effective in Vitro	/
Gokce et al (2012)^Citation13	Elizabethkingia	TMP-SMZ for 3 weeks	CSF examination returned to normal, but the patient developed hydrocephalus	No side-effects occurred

Abbreviations: CONS, coagulase-negative staphylococci; K. pneumoniae, Klebsiella pneumoniae; CRKP, Carbapenem-resistant Klebsiella pneumoniae; CAZ-AVI, ceftazidime avibactam; TMP-SMZ, trimethoprim–sulfamethoxazole; CSF, Cerebrospinal fluid.

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