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Infection and Drug Resistance Volume 14, 2021 - Issue
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Original Research

Analysis of Factors Influencing Multidrug-Resistant Tuberculosis and Validation of Whole-Genome Sequencing in Children with Drug-Resistant Tuberculosis

Ying Zhang1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Ruiqiu Zhao1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Zhenzhen Zhang1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Quanbo Liu1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Aihua Zhang1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Qiaoli Ren1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Siyuan Li1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Xiaoru Long1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Hongmei Xu1 Department of Infection, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, The Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
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Pages 4375-4393 | Published online: 24 Oct 2021

Figures & data

Figure 1 Continue.

Figure 1 Continue.

Figure 1 Distribution of 37 drug-resistant Mycobacterium tuberculosis isolates. (A) Distribution of drug-resistant strains by ratio method drug susceptibility test. (B) Distribution of drug-resistant strains by Whole-genome sequencing. (C) Distribution of drug-resistant types by the ratio method drug susceptibility test.

Abbreviations: AMK, Amikacin; DR, Drug-resistant; EMB, Ethambutol; XDR, Extensively drug-resistant; INH, Isoniazid; Lvfx, Levofloxacin; MFX, Moxifloxacin; MDR, Multidrug resistant; RIF, Rifampicin; pre-XDR, Pre-extensively drug-resistant; PTH, Prothionamide; RFT, Rifapentine; WGS, Whole-genome sequencing.
Figure 1 Distribution of 37 drug-resistant Mycobacterium tuberculosis isolates. (A) Distribution of drug-resistant strains by ratio method drug susceptibility test. (B) Distribution of drug-resistant strains by Whole-genome sequencing. (C) Distribution of drug-resistant types by the ratio method drug susceptibility test.

Table 1 Distribution of Mutation Sites in Drug Resistant Isolates and Drug Sensitivity Strains

Table 2 Genotype Distributions in Different Groups (n, %)

Table 3 Whole Genome Sequencing Compared with Phenotypic Drug Sensitivity Test in Drug Resistance Diagnosis of Mycobacterium tuberculosis Isolates

Table 4 Population Characteristics and Clinical Data of 208 Pediatric Tuberculosis Patients (n, %)

Table 5 The Distribution of Population Characteristics and Clinical Materials in Lineage 2 and Lineage 4 Groups (n, %)

Table 6 The Distribution of Clinical Materials in Severe and Non-Severe Patients (n, %)

Table 7 Factors Associated with Different Diagnosis of Tuberculosis in Children

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