Prevalence and Genotype Distribution of Human Papillomavirus Among Healthy Females in Beijing, China, 2016–2019

Figures & data

Figure 1 Constituent ratio of different age groups of HPV infection.

Figure 2 Distribution of HPV genotypes among healthy women.

Table 1 Frequency and Prevalence of Single and Multiple HPV Infection Among Healthy Women

Genotype	Positive Number	Prevalence (%)
Single	2897	9.84
Double	547	1.86
Triple	104	0.35
Quadruple	30	0.10
Quintet	7	0.02
Sextuple	1	0.01

Table 2 The Top Ten Combinations of Genotypes in HPV Double Infections

Combination of Types	Positive Number	Prevalence (%)
16+52	35	5.08
39+68	26	3.77
52+58	23	3.34
51+52	20	2.90
51+58	16	2.32
52+56	16	2.32
16+58	15	2.18
66+56	12	1.74
39+52	12	1.74
56+58	12	1.74

Figure 3 Prevalence of HPV grouped by age. (A) Prevalence of HPV infection in different age groups; (B) Prevalence of single and multiple infection of HPV in different age groups; (C) Prevalence of HPV16, 51, 52, 56, and 58 in different age groups.

Table 3 Comparison of Annual Total, Single, and Multiple Infection Rates of HPV from 2016 to 2019

Year	N	Total Infection, n (%)	Single, n (%)	Multiple, n (%)
2016	6398	796(12.44)	637(9.96)	159(2.49)
2017	8511	1016(11.94)	821(9.65)	195(2.29)
2018	7756	962(12.40)	787(10.15)	175(2.36)
2019	6771	812(11.99)	652(9.63)	160(2.36)
P-value		0.691	0.655	0.818

Table 4 Comparison the Prevalence of Different HPV Subtypes from 2016 to 2019

HPV subtype	2016, n (%)	2017, n (%)	2018, n (%)	2019, n (%)	P-value
HPV16	125(1.95%)	143(1.68%)	157(2.02%)	110(1.62%)	0.184
HPV18	56(0.88%)	51(0.60%)	52(0.67%)	40(0.59%)	0.153
HPV31	46(0.72%)	72(0.85%)	65(0.84%)	42(0.62%)	0.344
HPV33	33(0.52%)	36(0.42%)	31(0.40%)	32(0.47%)	0.735
HPV35	28(0.44%)	45(0.53%)	43(0.55%)	38(0.56%)	0.744
HPV39	69(1.08%)	67(0.79%)	81(1.04%)	48(0.71%)	0.044
HPV45	12(0.19%)	16(0.19%)	15(0.19%)	14(0.21%)	0.993
HPV51	72(1.13%)	85(1.00%)	91(1.17%)	98(1.45%)	0.081
HPV52	181(2.83%)	271(3.18%)	249(3.21%)	194(2.87%)	0.387
HPV56	71(1.11%)	80(0.94%)	91(1.17%)	69(1.02%)	0.497
HPV58	143(2.24%)	164(1.93%)	121(1.56%)	113(1.67%)	0.016
HPV59	34(0.53%)	40(0.47%)	66(0.85%)	46(0.68%)	0.013
HPV66	51(0.80%)	75(0.88%)	49(0.63%)	54(0.80%)	0.336
HPV68	39(0.61%)	44(0.52%)	56(0.72%)	74(1.09%)	0.000
HPV82	16(0.25%)	17(0.20%)	11(0.14%)	12(0.18%)	0.519
HPV (6+11)	21(0.33%)	48(0.56%)	18(0.23%)	32(0.47%)	0.005

Table 5 Comparison of HPV Infection Rate of Different Ages from 2016 to 2019

Age Groups (Years)	2016, n (%)	2017, n (%)	2018, n (%)	2019, n (%)	P-value
<25	13(22.41)	22(23.91)	17(20.00)	12(16.90)	0.726
25–29	62(17.87)	84(13.35)	108(16.22)	73(12.87)	0.096
30–34	107(15.71)	126(11.99)	110(10.61)	118(12.67)	0.018
35–39	96(10.67)	126(10.99)	110(9.80)	131(12.54)	0.234
40–44	125(11.94)	127(10.37)	117(11.93)	85(10.20)	0.429
45–49	119(10.59)	163(11.98)	152(13.15)	114(12.51)	0.286
50–54	118(10.92)	172(12.31)	120(11.58)	104(11.91)	0.753
55–59	72(13.82)	88(12.12)	114(14.92)	89(12.52)	0.376
60–64	52(14.40)	69(13.48)	67(12.52)	50(11.16)	0.541
≥65	32(11.51)	39(10.51)	47(12.57)	36(9.45)	0.564

Table 6 Comparison of HPV Infection Rates in Different Areas in China

Regions	Positive Number	Prevalence (%)	P-value
Beijing City	3586	12.18
Shanghai City^Citation19	6360	18.95	<0.001
Zhengzhou City^Citation20	6020	12.09	0.7
Wuhan City^Citation21	2436	17.68	<0.001
Xinjiang Province^Citation22	5287	14.02	<0.001
Jiangxi Province^Citation23	16,065	22.49	<0.001
Sichuan Province^Citation24	2641	24.11	<0.001
Yunnan Province^Citation25	3681	12.94	<0.001
Zhejiang Province^Citation26	197,367	20.54	<0.001
Guangdong Province^Citation27	5690	19.81	<0.001
Jiangsu Province^Citation28	16,775	26.92	<0.001
Shaanxi Province^Citation29	4263	30.21	<0.001
Shandong Province^Citation30	26,839	28.40	<0.001

Table 7 Prevalence of the Three Most Common HPV Genotypes of in Different Areas in China

Regions	N	Prevalence of Genotypes (%)
		HPV16	HPV52	HPV58
Beijing City	29,436	1.82	3.04	1.84
Shanghai City^Citation19	33,562	3.34	2.48	2.63
Zhengzhou City^Citation20	49,793	2.32	2.41	1.59
Wuhan City^Citation21	13,775	2.56	4.23	2.37
Xinjiang Province^Citation22	37,722	3.79	2.47	1.76
Jiangxi Province^Citation23	71,435	2.60	2.23	1.76
Sichuan Province^Citation24	10,953	3.33	3.74	3.21
Yunnan Province^Citation25	28,457	1.71	2.08	1.04
Zhejiang Province^Citation26	961,029	3.62	3.36	3.24
Guangdong Province^Citation27	28,730	5.01	2.63	1.91
Jiangsu Province^Citation28	62,317	5.06	5.09	3.14
Shaanxi Province^Citation29	14,111	10.71	5.24	5.43
Shandong Province^Citation30	94,489	5.77	5.14	3.46

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