In vitro Antimicrobial Activity Comparison of Linezolid, Tedizolid, Sutezolid and Delpazolid Against Slowly Growing Mycobacteria Isolated in Beijing, China

Figures & data

Table 1 MICs of LZD, TZD, SZD and DZD Against the Reference Strains of 20 SGM Species

Strain by Type	Mycobacterium Species (Strain)	MIC (µg/mL)
		LZD	TZD	SZD	DZD
ATCC 25276	Mycobacterium asiaticum	2	0.5	0.25	2
ATCC 25291	Mycobacterium avium	1	0.5	0.125	1
ATCC 51131	Mycobacterium celatum	8	2	0.5	4
DSM44623	Mycobacterium chimaera	1	0.063	0.063	0.5
ATCC 14470	Mycobacterium gordonae	0.5	0.125	0.25	0.5
ATCC 13950	Mycobacterium intracellulare	4	32	0.5	16
ATCC 12478	Mycobacterium kansassi	1	1	0.25	2
ATCC 33013	Mycobacterium komossense	0.5	0.063	2	0.5
ATCC 29571	Mycobacterium malmoense	4	2	0.25	1
ATCC 927	Mycobacterium marinum	0.5	0.125	0.5	0.25
ATCC 19530	Mycobacterium nonchromogenicum	0.5	0.03	0.5	0.13
BAA-614	Mycobacterium parascrofulaceum	4	2	0.5	2
ATCC 19981	Mycobacterium scrofulaceum	4	1	4	1
ATCC 27962	Mycobacterium shimoidei	1	0.5	0.03	1
ATCC 33027	Mycobacterium sphagni	0.25	0.03	0.5	0.25
ATCC 25275	Mycobacterium simiae	>32	8	2	8
ATCC 35799	Mycobacterium szulgai	1	0.5	0.25	1
ATCC 15755	Mycobacterium terrae	2	1	0.5	1
ATCC 19423	Mycobacterium ulcerans	0.13	0.13	0.03	0.25
ATCC 19250	Mycobacterium xenopi	4	2	0.25	4

Figure 1 The MIC distributions of M. intracellulare against LZD, TZD, SZD and DZD.

Figure 2 The MIC distributions of M. avium against LZD, TZD, SZD and DZD.

Figure 3 The MIC distributions of M. kansasii against LZD, TZD, SZD and DZD.

Table 2 The MICs of LZD and rplC, rplD and 23srRNA Mutations Against M. avium and M. intracellulare Isolates

MIC of LZD (μg/mL)	Species (NO.)	RplC	RplD	23SrRNA
0.5	M. avium (0)	—	—	—
	M. intracellulare (1)	WT(1)	WT(1)	WT(1)
1	M. avium (0)	—	—	—
	M. intracellulare (1)	WT(1)	WT(1)	T2420C(1)
2	M. avium (0)	—	—	—
	M. intracellulare (1)	WT(1)	WT(1)	T2420C(1)
4	M. avium (2)	WT(2)	WT(2)	WT(2)
	M. intracellulare (4)	WT(2) Val175Met(2)	WT(4)	WT(3) G1943A/ T2420C(1)
8	M. avium (3)	WT(3)	WT(3)	WT(3)
	M. intracellulare (6)	WT(6)	WT(6)	WT(5) A1929G/ T2420C(1)
16	M. avium (10)	WT(10)	WT (9) Thr147Ala (1)	WT(9) C2078T(1)
	M. intracellulare (13)	WT(13)	WT(13)	WT(7) T2420C(5) G1943A(1)
32	M. avium (3)	WT(3)	WT(2) Thr147Ala (1)	WT(3)
	M. intracellulare (14)	WT(14)	WT(14)	WT(8) T2420C(4) A2267C(1) A2266G(1)
>32	M. avium (23)	WT(23)	WT(22) Thr147Ala (1)	WT(22) Ins^a 2407G(1)
	M. intracellulare (8)	WT(8)	WT(8)	WT(6) T2420C(1) A2266C(1)

Note: ^aIns, insertion.