In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020

Figures & data

Table 1 MIC-Related Parameters from Different Specimens

Specimens (No.Tested)	Vancomycin (mg/L)			Teicoplanin (mg/L)			Linezolid (mg/L)			Daptomycin (mg/L)
	MIC50	MIC90	GM MIC	MIC50	MIC90	GM MIC	MIC50	MIC90	GM MIC	MIC50	MIC90	GM MIC
Blood (n = 132)	0.5	1	0.53	0.25	1	0.36	1	1.9	0.84	0.25	0.5	0.22
Pus (n = 117)	0.5	1	0.53	0.25	0.5	0.33	1	2	0.90	0.25	0.5	0.25
Sputum (n = 158)	0.5	1	0.54	0.5	1	0.47	1	2	0.88	0.25	05	0.26

Table 2 MIC-Related Parameters from Different Regions

Hospitals	Number of Tested	MIC Related Parameters	Vancomycin (mg/L)	Teicoplanin (mg/L)	Linezolid (mg/L)	Daptomycin (mg/L)
Zhejiang	107	GM MIC	0.49	0.28	0.68	0.17
		MIC50	0.5	0.25	1	0.125
		MIC90	0.5	0.5	1	0.25
		MIC range	0.25–2	0.125–1	0.25–2	0.06–1
Jiangxi	24	GM MIC	0.56	0.33	0.77	0.23
		MIC50	0.5	0.25	1	0.25
		MIC90	1	0.5	1	0.25
		MIC range	0.25–1	0.25–0.5	0.5–1	0.06–1
Hubei	38	GM MIC	0.49	0.60	0.80	0.25
		MIC50	0.5	0.5	1	0.25
		MIC90	1	2	1	0.25
		MIC range	0.25–1	0.25–2	0.5–2	0.125–1
Sichuan	94	GM MIC	0.54	0.42	1.08	0.25
		MIC50	0.5	0.5	1	0.25
		MIC90	0.85	1	2	0.5
		MIC range	0.25–2	0.125–4	0.25–4	0.06–1
Guangdong	62	GM MIC	0.59	0.43	0.85	0.36
		MIC50	0.5	0.5	1	0.5
		MIC90	1	1	1	0.5
		MIC range	0.5–1	0.125–2	0.5–4	0.125–1
Shanghai	82	GM MIC	0.58	0.45	1.05	0.29
		MIC50	0.5	0.5	1	0.25
		MIC90	1	1	2	0.5
		MIC range	0.25–1	0.125–2	0.25–4	0.125–1

Table 3 MIC-Related Parameters, 2018–2020

Antibiotics	Year	GM MIC (mg/L)	MIC Range (mg/L)	MIC50 (mg/L)	MIC90 (mg/L)
Vancomycin	2018	0.57	0.25–1	0.5	1
	2019	0.52	0.25–1	0.5	1
	2020	0.53	0.25–2	0.5	1
Teicoplanin	2018	0.44	0.125–2	0.5	1
	2019	0.37	0.125–4	0.25	1
	2020	0.36	0.125–2	0.5	0.5
Linezolid	2018	0.90	0.5–2	0.5	1
	2019	0.84	0.25–4	1	2
	2020	0.88	0.25–4	1	2
Daptomycin	2018	0.28	0.06–1	0.5	0.5
	2019	0.23	0.06–1	0.5	0.5
	2020	0.23	0.06–1	0.25	0.5

Figure 1 Trend over time of antimicrobial susceptibility of MRSA isolates in 2018 (n = 135), in 2019 (n = 141), and 2020 (n = 131) against vancomycin (A) teicoplanin (B) linezolid (C) and daptomycin (D).

Table 4 MIC Values of Teicoplanin, Linezolid and Daptomycin Stratified by MIC Values of Vancomycin

Antibacterials	Vancomycin MIC (mg/L)	MIC50 (mg/L)	MIC90 (mg/L)	MIC Range (mg/L)	GM MIC (mg/L)
Teicoplanin	< 1	0.25	1	0.125–4	0.40
	≥ 1	0.5	1.5	0.25–2	0.59
Linezolid	< 1	1	2	0.25–4	0.89
	≥ 1	1	2	0.5–4	0.97
Daptomycin	< 1	0.25	0.5	0.06–1	0.25
	≥ 1	0.25	0.5	0.125–1	0.30