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Infection and Drug Resistance Volume 15, 2022 - Issue
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SHORT REPORT

Co-Production of NDM-1 and OXA-10 β-Lactamase in Citrobacter braakii Strain Causing Urinary Tract Infection

Huiming Han1 School of Basic Medical Sciences, Beihua University, Jilin, Jilin Province, People’s Republic of China
,
Zhi Zhao2 Department of Neonatology, Shaanxi Province People’s Hospital, Xi’an, Shaanxi Province, People’s Republic of China
,
Yan Lin1 School of Basic Medical Sciences, Beihua University, Jilin, Jilin Province, People’s Republic of China
,
Baihui Lin1 School of Basic Medical Sciences, Beihua University, Jilin, Jilin Province, People’s Republic of China
,
Hao Xu3 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China
&
Beiwen Zheng3 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence[email protected]
Pages 1127-1133 | Published online: 19 Mar 2022

Figures & data

Table 1 Characteristics of ARGs Carried by DY2019

Figure 1 Plasmid profiles and Southern blot-hybridization of C. braakii DY2019. Southern blot-hybridization of S1-nuclease digested DNA using a specific probe (blaNDM). M: XbaI digested total DNA of Salmonella enterica serotype Braenderup H9812 as a size marker and Enterobacter cloacae DY1901 as the control.

Figure 1 Plasmid profiles and Southern blot-hybridization of C. braakii DY2019. Southern blot-hybridization of S1-nuclease digested DNA using a specific probe (blaNDM). M: XbaI digested total DNA of Salmonella enterica serotype Braenderup H9812 as a size marker and Enterobacter cloacae DY1901 as the control.

Figure 2 Major structural features and comparison of beta-lactamase-encoding plasmids. (A) Schematic illustration showing the structural features of pDY2019-NDM. (B) Linear maps of five NDM-1 encoding plasmids, pDY2019-NDM, pCC1-1/2b (MT559998), pKC3-1/2b (MT560001), pPmi70746_1 (CP023274), and AR_0156 plasmid unitig_1 (CP021853). ORFs are portrayed by arrows and colored according to their putative functions. The alignment of the plasmids was performed and visualized by BLAST ring image generator (BRIG) software.

Figure 2 Major structural features and comparison of beta-lactamase-encoding plasmids. (A) Schematic illustration showing the structural features of pDY2019-NDM. (B) Linear maps of five NDM-1 encoding plasmids, pDY2019-NDM, pCC1-1/2b (MT559998), pKC3-1/2b (MT560001), pPmi70746_1 (CP023274), and AR_0156 plasmid unitig_1 (CP021853). ORFs are portrayed by arrows and colored according to their putative functions. The alignment of the plasmids was performed and visualized by BLAST ring image generator (BRIG) software.

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