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Infection and Drug Resistance Volume 15, 2022 - Issue
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ORIGINAL RESEARCH

Excessively Prolonged Early Antibiotic Duration in Very-Low-Birth-Weight Infants: A Multicenter Prospective Cohort Study in a Developing Country

Shanshan Hou1 Department of Neonatology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, People’s Republic of China;2 Department of Pediatric, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, People’s Republic of ChinaView further author information
,
Xiaokang Wang3 Department of Neonatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of ChinaView further author information
,
Fang Wang4 Department of Neonatology, Liaocheng People’s Hospital, Liaocheng, 252000, People’s Republic of ChinaView further author information
,
Zhongliang Li5 Department of Neonatology, W.F. Maternal and Child Health Hospital, Weifang, 261011, People’s Republic of ChinaView further author information
,
Hui Wang6 Department of Neonatology, Hebei PetroChina Central Hospital, Langfang, 065000, People’s Republic of ChinaView further author information
,
Jiahui Li7 Department of Neonatology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, People’s Republic of ChinaView further author information
,
Jing Wang8 Department of Neonatology, Women and Children’s Healthcare Hospital of Linyi, Linyi, 276000, People’s Republic of ChinaView further author information
,
Haiying He9 Department of Neonatology, Baogang Third Hospital of Hongci Group, Baotou, 014010, People’s Republic of ChinaView further author information
,
Liping Deng10 Department of Neonatology, Heze Municipal Hospital, Heze, 274031, People’s Republic of ChinaView further author information
,
Yushu Feng11 Department of Neonatology, Linyi People’s Hospital, Linyi, 276000, People’s Republic of ChinaView further author information
,
Xiufang Fan12 Department of Neonatology, Jinan Maternity and Child Health Care Hospital, Jinan, 250001, People’s Republic of ChinaView further author information
,
Wen Li13 Department of Neonatology, Qilu Hospital of Shandong University, Jinan, 250012, People’s Republic of ChinaView further author information
,
Qinghua Lu14 Department of Neonatology, Shandong Maternal and Child Health Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250014, People’s Republic of ChinaView further author information
,
Yanying Ma15 Department of Neonatology, Jinan Second Maternal and Child Health Care Hospital, Jinan, 271100, People’s Republic of ChinaView further author information
,
Guoying Zhao16 Department of Neonatology, Binzhou Medical University Hospital, Binzhou, 256603, People’s Republic of ChinaView further author information
,
Simmy Reddy17 Cheeloo College of Medicine, Shandong University, Jinan, 250021, People’s Republic of ChinaView further author information
,
Yanqiu Wu2 Department of Pediatric, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Yonghui Yu1 Department of Neonatology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, People’s Republic of China;3 Department of Neonatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
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Pages 1921-1931 | Published online: 19 Apr 2022

Figures & data

Table 1 Descriptive Characteristics Comparison of Short and Prolonged Early Antibiotic Course

Figure 1 Flowchart of the study and distribution of DOT/1000Pd for early antibiotic use.

Abbreviations: NICU, neonatal intensive care units; EOS, early onset sepsis; DOT, days of therapy.
Figure 1 Flowchart of the study and distribution of DOT/1000Pd for early antibiotic use.

Table 2 Antibiotic Metrics Comparison of Short and Prolonged Early Antibiotic Courses

Figure 2 Distribution of duration of early antibiotic courses in VLBW infants.

Abbreviations: EOS; early onset sepsis. d, days.
Figure 2 Distribution of duration of early antibiotic courses in VLBW infants.

Figure 3 Early antibiotic classes used by DOT/1000PD.

Abbreviations: TGC, third generation cephalosporins; SGC, second generation cephalosporins; FGC, fourth generation cephalosporins.
Figure 3 Early antibiotic classes used by DOT/1000PD.

Table 3 Antibiotic Resistance Patterns of Isolated Pathogens

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