Septic Shock, Renal Abscess, and Bacteremia Due to Peptoniphilus asaccharolyticus in a Woman with Nephrosis and Diabetes Mellitus: Case Report and Literature Review

Figures & data

Figure 1 Colonies and microscopic morphology of Peptoniphilus asaccharolyticus. (A) Direct gram stain of the positive anaerobic bottles, 1000×. (B) Colonies on blood agar from anaerobic cultivation for 48 h. (C) Gram stain of the colonies on blood agar, 1000×.

Table 1 Reports with Detailed Descriptions of Monomicrobial Infections Due to Peptoniphilus asaccharolyticus (as of December 2021)

Reference	Age	Sex	Diagnosis	Risk Factors	History Disease	Culture Positive	Treatment	Outcome	Year	Country
1^Citation6	55	F	Septic arthritis and osteomyelitis	Pyelonephritis in the preceding month	Diabetes, hypertension, hypothyroidism, asthma, dyslipidemia, depression, obesity, degenerative joint disease of the hip, cholecystectomy, and bilateral shoulder arthroplasties	Hip joint aspirate and tissue	Ceftriaxone and total hip arthroplasty, incision and drainage of the joint, and debridement.	Improved	2017	United States
2^Citation3	62	F	Early prosthetic joint infection	An uncomplicated total hip replacement 2 weeks earlier	None	Intraoperative deep-tissue samples	Cefuroxime, revision surgery, inlay and femoral head replacement.	Not mentioned	2019	Germany
3^Citation12	11	M	Renal abscess		Coarctation of the aorta repaired at age 11 months of a11 and a bicuspid aortic valve	Aspiration of renal abscess	Clindamycin, gentamicin, and percutaneous drainage of abscess	Improved	2001	United States
4^Citation17	82	M	Urinary tract infection with associated bacteremia	None	Former alcoholic with benign prostatic hypertrophy	Blood	Oxacillin, gentamicin, trimethoprim–sulfamethoxazole	Improved	1980	United States
5^Citation16	57	F	Septic arthritis	A dental procedure (tartar removal) two months ago	Peripheral spondyloarthritis	Synovial fluid of right knee	Amoxicillin, clavulanic acid and Right knee arthrocentesis	Improved	2016	Portugal
This report	49	F	Septic shock, renal abscess, and bacteremia	Double J tube removal	Diabetes mellitus, hypertension, cholecystectomy, renal clear cell carcinoma (grade II–III), and bilateral renal stone	Abscess, blood	Imipenem and drainage of perinephric abscess	Improved	2020	China

Verma R, Morrad S, Wirtz JJ. Peptoniphilus asaccharolyticus-associated septic arthritis and osteomyelitis in a woman with osteoarthritis and diabetes mellitus. BMJ Case Rep. 2017:bcr-2017-219969. doi:10.1136/bcr-2017-219969

 Google Scholar

Müller-Schulte E, Heimann KC, Treder W. Peptoniphilus asaccharolyticus - Commensal, pathogen or synergist? Two case reports on invasive Peptoniphilus asaccharolyticus infection. Anaerobe. 2019;59:159–162. doi:10.1016/j.anaerobe.2019.07.001

 PubMed Web of Science ®Google Scholar

Casullo VA, Bottone E, Herold BC. Peptostreptococcus asaccharolyticus renal abscess: a rare cause of fever of unknown origin. Pediatrics. 2001;107(1):E11. doi:10.1542/peds.107.1.e11

 Web of Science ®Google Scholar

Stella GJ. Peptococcla urinary tract infection with bacteremia: a case report. J Urol. 1980;124(1):158–159. doi:10.1016/S0022-5347(17)55342-2

 PubMed Web of Science ®Google Scholar

Costa C, Santiago M, Ferreira J, et al. Septic arthritis caused by Peptostreptococcus asaccharolyticus. Acta Reumatologica Portuguesa. 2016;41(3):271–272.

 Web of Science ®Google Scholar