Characterization of Silver Resistance and Coexistence of sil Operon with Antibiotic Resistance Genes Among Gram-Negative Pathogens Isolated from Wound Samples by Using Whole-Genome Sequencing

Haichen Wang1 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of ChinaView further author information

Jia Li2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;3 Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information

Changhang Min1 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of ChinaView further author information

Fengjun Xia1 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China

https://orcid.org/0000-0001-9871-0366 View further author information

Mengli Tang1 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of ChinaView further author information

Jun Li1 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of ChinaView further author information

Yongmei Hu1 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of ChinaView further author information

Mingxiang Zou1 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China;2 Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of ChinaCorrespondence[email protected]
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Characterization of Silver Resistance and Coexistence of sil Operon with Antibiotic Resistance Genes Among Gram-Negative Pathogens Isolated from Wound Samples by Using Whole-Genome Sequencing

Table 1 Overall Identities of sil Genes Compared with pMG101

Table 2 Antibiotic Resistance Genes and Plasmid Inc Type Among Gram-Negative Pathogens Harboring sil Operon

Table 3 Antimicrobial Susceptibility Profiles in Enterobacteriaceae (n=125)

Table 4 In vitro Selection of Ag⁺ Resistance Mutants of the silS-Positive Strains

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Characterization of Silver Resistance and Coexistence of sil Operon with Antibiotic Resistance Genes Among Gram-Negative Pathogens Isolated from Wound Samples by Using Whole-Genome Sequencing

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Table 1 Overall Identities of sil Genes Compared with pMG101

Table 2 Antibiotic Resistance Genes and Plasmid Inc Type Among Gram-Negative Pathogens Harboring sil Operon

Table 3 Antimicrobial Susceptibility Profiles in Enterobacteriaceae (n=125)

Table 4 In vitro Selection of Ag+ Resistance Mutants of the silS-Positive Strains

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Table 4 In vitro Selection of Ag⁺ Resistance Mutants of the silS-Positive Strains