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Infection and Drug Resistance Volume 15, 2022 - Issue
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RESEARCH LETTER

Characterization of an Extensively Drug-Resistant Salmonella enterica Serovar Indiana Strain Harboring Chromosomal blaNDM-9 in China

Jing Wang1 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;2 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;3 Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of ChinaView further author information
,
Yue Jiang1 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;2 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of ChinaView further author information
,
Cai-Yue Mei1 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;2 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of ChinaView further author information
,
Zhen-Yu Wang1 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;2 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of ChinaView further author information
,
Fa-Gang Zhong4 State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Institute of Animal Husbandry and Veterinary, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, Xinjiang Province, People’s Republic of ChinaView further author information
,
Xing-Xing Zhang4 State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Institute of Animal Husbandry and Veterinary, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, Xinjiang Province, People’s Republic of ChinaView further author information
,
Lu-Chao Lv5 College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province, People’s Republic of ChinaView further author information
,
Meng-Jun Lu1 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;2 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of ChinaView further author information
,
Han Wu1 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;2 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of ChinaView further author information
&
Xinan Jiao1 Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;2 Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China;3 Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2214-3358View further author information
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Pages 2015-2019 | Published online: 20 Apr 2022

Figures & data

Figure 1 Continued.

Figure 1 Continued.

Figure 1 (A) Genetic structures of the multiresistance region I in chromosome of the isolate YZ21MCS4 in this study and comparison with other plasmids. Resistance genes are shown in red. Genes on chromosome of Salmonella Indiana are shown in green. Δ indicates a truncated gene or mobile element. ISs are shown as boxes labeled with their name. Tall bars represent the inverted repeats (IRs) of transposons or integron. (B) Proposed mechanism for the formation of multiresistance region I and its neighboring region in YZ21MCS4. It is not drawn to scale. Chromosomal DNA segments are represented by the same shape colored blue or red. Direct repeats are indicated by arrows and sequences. (C) Genetic structures of the multiresistance region II in YZ21MCS4 compared with similar structures. Resistance genes are shown in red. Genes on chromosome of Salmonella Indiana are shown in green. Δ indicates a truncated gene or mobile element. Tall bars represent the inverted repeats (IRs) of transposons.

Figure 1 (A) Genetic structures of the multiresistance region I in chromosome of the isolate YZ21MCS4 in this study and comparison with other plasmids. Resistance genes are shown in red. Genes on chromosome of Salmonella Indiana are shown in green. Δ indicates a truncated gene or mobile element. ISs are shown as boxes labeled with their name. Tall bars represent the inverted repeats (IRs) of transposons or integron. (B) Proposed mechanism for the formation of multiresistance region I and its neighboring region in YZ21MCS4. It is not drawn to scale. Chromosomal DNA segments are represented by the same shape colored blue or red. Direct repeats are indicated by arrows and sequences. (C) Genetic structures of the multiresistance region II in YZ21MCS4 compared with similar structures. Resistance genes are shown in red. Genes on chromosome of Salmonella Indiana are shown in green. Δ indicates a truncated gene or mobile element. Tall bars represent the inverted repeats (IRs) of transposons.

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