The Human Papillomavirus Infection Characteristics for Patients with Cervical Intraepithelial Neoplasia in Yunnan, China: A Sampling Survey Analysis

Figures & data

Table 1 Distribution of Patients’ Age in Different CINs

Age (Year)	LSIL	HSIL
	Cases (%)	Cases (%)
<30	13(16)	25(12)
30~45	32(41)	117(58)
>45	34(43)	60(30)
Total	79	202

Figure 1 33-year-old female with HPV35 infection in cervical H&E. Atypical cell extended above the lower third of the mucosa.

Figure 2 Streptavidin–peroxidase method. P16 was block-positive reactivity.

Figure 3 Streptavidin–peroxidase method. High Ki-67 index.

Table 2 Analysis of Single and Multiple HPV Infections in CIN Patients at Different Age Groups

Age	LSIL					HSIL
	Single	Multiple				Single	Multiple
	One	Two	Three	Four	Five	One	Two	Three	Four	Five
<30	9(11%)	3(4%)	0	1(1%)	0	23(11%)	2(1%)	0	0	0
30~45	27(34%)	4(5%)	0	1(1%)	0	83(41%)	22(11%)	7(3%)	4(2%)	0
>45	23(29%)	7(9%)	2(3%)	1(1%)	1(1%)	48(24%)	7(3%)	3(1%)	2(1%)	1(0.4%)
Total	59(75%)	14(18%)	2(3%)	3(4%)	1(1%)	154(76%)	31(15%)	10(5%)	6(3%)	1(0.4%)
	59(75%)	20(25%)				154(76%)	48(24%)
X^2	2.797					5.037
P	0.258					0.081

Table 3 Distribution Characteristics of HPV Subtypes in Different CINs

HPV Types		LSIL				HSIL
		Single	Total%	Multiple	Total%	Single	Total%	Multiple	Total%
HR-HPV	16	7	8.0	7	8.0	76	30.5	22	8.5
	18	5	5.7	0		4	1.5	4	1.5
	31	1	1.1	1	1.1	1	0.4	6	2.3
	33	0		2	2.3	8	3.1	9	3.5
	35	0		0		4	1.5	5	1.9
	39	0		1	1.1	1	0.4	3	1.2
	45	0		0		0		1	0.4
	51	3	3.4	4	4.6	4	1.5	9	3.5
	52	17	19.5	5	5.7	17	6.6	12	4.6
	53	3	3.4	2	2.3	3	1.2	5	1.9
	56	1	1.1	4	4.6	2	0.8	3	1.2
	58	10	11.5	4	4.6	26	10.0	14	5.4
	59	2	2.3	0		2	0.8	4	1.5
	66	1	1.1	1	1.1	1	0.4	3	1.2
	68	3	3.4	3	3.4	1	0.4	2	0.8
	73	0		0		0		2	0.8
	82	0		0		1	0.4	4	1.5
	Total	87				259
LR-HPV	6	0		3	14.3	0		1	5.9
	11	0		1	4.8	0		3	17.6
	40	1	4.8	0		0		0
	42	2	9.5	2	9.5	0		0
	43	2	9.5	3	14.3	1	5.9	4	23.5
	55	0		1	4.8	0		1	5.9
	61	0		4	19.0	0		2	11.8
	81	0		2	9.5	1	5.9	4	23.5
	Total	21				17

Table 4 The Infection Characteristics of HPV in Different Nations

	LISL		HISL
	Single	Multiple	Single	Multiple
Han	39	15	131	41
National minority	19	6	22	8
χ^2	0.006		0.011
P	0.937		0.918

Abbreviations: HPV, human papillomavirus; HISL, high-grade squamous intraepithelial lesion; LISL, low-grade squamous intraepithelial lesion.