The Dissemination of Fusidic Acid Resistance Among Staphylococcus epidermidis Clinical Isolates in Wenzhou, China

Figures & data

Table 1 Distribution of FA MIC Levels in S. epidermidis Isolates

No. of S. epidermidis (%)	No. of Isolates with Different Fusidic Acid MIC (μg/mL)
	4	8	16	32
55	2 (3.6%)	7 (12.7%)	39 (71.0%)	7 (12.7%)

Table 2 Prevalence of Antibiotic Resistance in FA-Resistant S. epidermidis

Antibiotics	FA-Resistant S. epidermidis (%)
Erythromycin	44 (80.0)
Clindamycin	36 (65.5)
Trimethoprim-sulfamethoxazole	36 (65.5)
Ciprofloxacin	35 (63.6)
Gentamicin	27 (49.1)
Rifampin	26 (47.3)
Tetracycline	13 (23.6)

Table 3 The Comparison of Drug Resistance Between ST2 Type and Non-ST2 in FA-Resistant S. epidermidis

Antimicrobial Agents	ST2	Non-ST2
	N=24	N=31
	R (n)	R (n)
Tetracycline	0.0% (0)	41.9% (13)
Gentamicin	91.7% (22)	16.1% (9)
Penicillin	100.0% (24)	96.7% (30)
Clindamycin	66.7% (16)	67.6% (21)
Erythromycin	62.5% (15)	96.7% (30)
Ciprofloxacin	95.8% (23)	9.6% (3)
Linezolid	0.0% (0)	0.0% (0)
Rifampicin	91.7% (22)	12.9% (4)
Trimethoprim-sulfamethoxazole	91.7% (22)	41.9% (13)
Levofloxacin	91.7% (22)	12.9% (4)
Vancomycin	0.00% (0)	0.00% (0)
Moxifloxacin	54.2% (13)	3.2% (1)

Figure 1 Results of PFGE and molecular characteristics of FA-resistant S. epidermidis isolates.

Figure 2 The value represents the ST type name, the blue point is the CC type Founder, the yellow dot is Subgroup founder, the black dot is all other ST types, and the dot size indicates the number of CC types. The solid line between the two points indicates that there is only one housekeeping gene difference between the two ST types.